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CDA 11-217 – HSR&D Study

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CDA 11-217
Risk Stratification and Targeted Therapy for HELP Diseases in Veterans
Akbar K Waljee MD MSc
VA Ann Arbor Healthcare System, Ann Arbor, MI
Ann Arbor, MI
Funding Period: September 2012 - August 2017

BACKGROUND/RATIONALE:
Veterans with "High Expense, Low Prevalence" (HELP) diseases such as rheumatoid arthritis, multiple sclerosis, and inflammatory bowel disease often have exacerbations that can result in mortality or major morbidity. Although some of these patients require lifelong, expensive, and potentially harmful medications to prevent serious complications, many others are at lower risk and are best treated with less expensive and less harmful medications, or by using "as-needed" therapy as flares occur. Therefore, stratifying veterans with HELP diseases into those at higher vs. lower risk offers great promise to significantly improve both the quality and efficiency of veteran care.

OBJECTIVE(S):
Aim 1: To compare the accuracy and calibration of traditional regression models vs. machine learning models for predicting IBD exacerbations.
Aim 2: To develop a microsimulation-based decision analytic model of targeted-prevention versus symptom-driven disease management in patients with IBD.
Aim 3: To develop and pilot a personalized medical decision support tool for IBD veterans.


METHODS:
We used a retrospective cohort of Veterans with IBD (fiscal years 1999-2016) to create models using logistic regression and machine learning methods (random forest, RF) to evaluate outcomes. Patients were identified using a combination of inpatient and outpatient ICD-9 codes for Crohn's disease (555.x), and ulcerative colitis (556.x). Much of the time in Years 1-2 was spent cleaning data and obtaining predictor variables. The variables were then used to evaluate multiple outcomes and to construct a model that could accurately predict endpoints (e.g. outpatient corticosteroid use and hospitalizations as a surrogate for IBD flare).
In years 2-3, we developed a simulation model comparing a biomarker-driven strategy based on the risk prediction models to a symptom-driven disease management (usual care) strategy, as well as assessing a combination approach. The clinical and economic effects of the two strategies were then compared (Aim 2). Years 4-5, we compared the accuracy of regression models and machine learning approaches for predicting exacerbations of disease and evaluating the performance characteristics (Aim 1).

FINDINGS/RESULTS:
Not yet available.

IMPACT:
Producing tools and decision-aids to help guide clinicians in personalizing medical decision-making for HELP diseases is particularly useful for VA, since having a subspecialist physician at every facility is not feasible. Having risk stratification tools developed and validated on the veteran population is therefore an important goal to realize efficient patient-centered care for HELP diseases through VA. Such tools would allow targeted intervention in patients at the highest risk of disease exacerbations and complications, reduce treatment-related adverse events and improve cost-effectiveness by de-escalating treatment in patients at low risk of disease exacerbation or complications.

PUBLICATIONS:

Journal Articles

  1. Noureldin M, Newman KL, Higgins PDR, Piette JD, Resnicow K, Louissaint J, Kenney B, Berinstein J, Waljee AK, Zhu J, Cohen-Mekelburg S. Profiles of Web-based Portal Users with Inflammatory Bowel Disease. Inflammatory Bowel Diseases. 2024 Jan 5; 30(1):83-89.
  2. Cohen-Mekelburg S, Jordan A, Kenney B, Burgess HJ, Chang JW, Hu HM, Tapper E, Langa KM, Levine DA, Waljee AK. Loneliness and Depressive Symptoms Are High Among Older Adults With Digestive Disease and Associated With Lower Perceived Health. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 2024 Mar 1; 22(3):621-629.e2.
  3. Gan RW, Sun D, Tatro AR, Cohen-Mekelburg S, Wiitala WL, Zhu J, Waljee AK. Replicating prediction algorithms for hospitalization and corticosteroid use in patients with inflammatory bowel disease. PLoS ONE. 2021 Sep 20; 16(9):e0257520.
  4. Berinstein JA, Cohen-Mekelburg SA, Greenberg GM, Wray D, Berry SK, Saini SD, Fendrick AM, Adams MA, Waljee AK, Higgins PDR. A Care Coordination Intervention Improves Symptoms But Not Charges in High-Risk Patients With Inflammatory Bowel Disease. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 2022 May 1; 20(5):1029-1038.e9.
  5. Berinstein JA, Sheehan JL, Dias M, Berinstein EM, Steiner CA, Johnson LA, Regal RE, Allen JI, Cushing KC, Stidham RW, Bishu S, Kinnucan JAR, Cohen-Mekelburg SA, Waljee AK, Higgins PDR. Tofacitinib for Biologic-Experienced Hospitalized Patients With Acute Severe Ulcerative Colitis: A Retrospective Case-Control Study. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 2021 Oct 1; 19(10):2112-2120.e1.
  6. Berinstein JA, Cohen-Mekelburg SA, Steiner CA, McLeod M, Noureldin M, Allen JI, Kullgren JT, Waljee AK, Higgins PDR. Variations in Health Care Utilization Patterns Among Inflammatory Bowel Disease Patients at Risk for High Medical Service Utilization Enrolled in High Deductible Health Plans. Inflammatory Bowel Diseases. 2021 May 17; 27(6):771-778.
  7. Wallace BI, Kenney B, Malani PN, Clauw DJ, Nallamothu BK, Waljee AK. Prevalence of Immunosuppressive Drug Use Among Commercially Insured US Adults, 2018-2019. JAMA Network Open. 2021 May 3; 4(5):e214920.
  8. Noureldin M, Cohen-Mekelburg S, Mahmood A, Stidham R, Higgins PDR, Govani S, Deshpande AR, Waljee AK. Trends of 5-Aminosalicylate Medication Use in Patients With Crohn Disease. Inflammatory Bowel Diseases. 2021 Mar 15; 27(4):516-521.
  9. Cohen-Mekelburg S, Wallace BI, Van T, Wiitala WL, Govani SM, Burns J, Lipson R, Yun H, Hou J, Lewis JD, Dominitz JA, Waljee AK. Association of Anti-Tumor Necrosis Factor Therapy With Mortality Among Veterans With Inflammatory Bowel Disease. JAMA Network Open. 2021 Mar 1; 4(3):e210313.
  10. Read AJ, Waljee AK, Chen CS, Holleman R, Kumbier KE, Saini SD. Prevalence of Appropriate Testing for Incident Anemia in the US Department of Veterans Affairs. JAMA Network Open. 2021 Jan 4; 4(1):e2034406.
  11. Iwashyna TJ, Ma C, Wang XQ, Seelye S, Zhu J, Waljee AK. Variation in model performance by data cleanliness and classification methods in the prediction of 30-day ICU mortality, a US nationwide retrospective cohort and simulation study. BMJ open. 2020 Dec 2; 10(12):e041421.
  12. Cohen-Mekelburg S, Waljee AK. Inflammatory Bowel Disease in the Older Adult. Clinics in geriatric medicine. 2021 Feb 1; 37(1):185-195.
  13. Waljee AK, Noureldin M, Berinstein JA, Cohen-Mekelburg SA, Wallace BI, Cushing KC, Hanauer DA, Keeney-Bonthrone TP, Nallamothu B, Higgins PDR. Mapping the relationships between inflammatory bowel disease and comorbid diagnoses to identify disease associations. European journal of gastroenterology & hepatology. 2020 Oct 1; 32(10):1341-1347.
  14. Cohen-Mekelburg S, Saini SD, Krein SL, Hofer TP, Wallace BI, Hollingsworth JM, Bynum JPW, Wiitala W, Burns J, Higgins PDR, Waljee AK. Association of Continuity of Care With Outcomes in US Veterans With Inflammatory Bowel Disease. JAMA Network Open. 2020 Sep 1; 3(9):e2015899.
  15. Thakur ER, Sansgiry S, Kramer JR, Waljee AK, Gaidos JK, Feagins LA, Govani SM, Dindo L, El-Serag HB, Hou JK. The Incidence and Prevalence of Anxiety, Depression, and Post-traumatic Stress Disorder in a National Cohort of US Veterans With Inflammatory Bowel Disease. Inflammatory Bowel Diseases. 2020 Aug 20; 26(9):1423-1428.
  16. Thompson AN, Cohen-Mekelburg S, Udow-Philllips M, Good CB, Waljee AK. Dissecting Drug Pricing in Gastroenterology and Hepatology. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 2021 Jan 1; 19(1):10-13.e1.
  17. Tavakkoli A, Elmunzer BJ, Waljee AK, Murphy CC, Pruitt SL, Zhu H, Rong R, Kwon RS, Scheiman JM, Rubenstein JH, Singal AG. Survival analysis among unresectable pancreatic adenocarcinoma patients undergoing endoscopic or percutaneous interventions. Gastrointestinal endoscopy. 2021 Jan 1; 93(1):154-162.e5.
  18. Gregory MH, Ciorba MA, Wiitala WL, Stidham RW, Higgins P, Morley SC, Hou JK, Feagins LA, Govani SM, Cohen-Mekelburg SA, Waljee AK. The Association of Medications and Vaccination with Risk of Pneumonia in Inflammatory Bowel Disease. Inflammatory Bowel Diseases. 2020 May 12; 26(6):919-925.
  19. Stidham RW, Enchakalody B, Waljee AK, Higgins PDR, Wang SC, Su GL, Wasnik AP, Al-Hawary M. Assessing Small Bowel Stricturing and Morphology in Crohn's Disease Using Semi-automated Image Analysis. Inflammatory Bowel Diseases. 2020 Apr 11; 26(5):734-742.
  20. Mahmoudi E, Kamdar N, Kim N, Gonzales G, Singh K, Waljee AK. Use of electronic medical records in development and validation of risk prediction models of hospital readmission: systematic review. BMJ (Clinical research ed.). 2020 Apr 8; 369:m958.
  21. Rubenstein JH, McConnell D, Waljee AK, Metko V, Nofz K, Khodadost M, Jiang L, Raghunathan T. Validation and Comparison of Tools for Selecting Individuals to Screen for Barrett's Esophagus and Early Neoplasia. Gastroenterology. 2020 Jun 1; 158(8):2082-2092.
  22. Limsrivilai J, Saleh ZM, Johnson LA, Stidham RW, Waljee AK, Govani SM, Gutermuth B, Brown AM, Briggs E, Rao K, Higgins PDR. Prevalence and Effect of Intestinal Infections Detected by a PCR-Based Stool Test in Patients with Inflammatory Bowel Disease. Digestive diseases and sciences. 2020 Nov 1; 65(11):3287-3296.
  23. Waljee AK, Higgins PDR, Jensen CB, Villumsen M, Cohen-Mekelburg SA, Wallace BI, Berinstein JA, Allin KH, Jess T. Anti-tumour necrosis factor-a therapy and recurrent or new primary cancers in patients with inflammatory bowel disease, rheumatoid arthritis, or psoriasis and previous cancer in Denmark: a nationwide, population-based cohort study. The lancet. Gastroenterology & hepatology. 2020 Mar 1; 5(3):276-284.
  24. Govani SM, Berinstein JA, Waljee AK, Stidham RW, Higgins PDR, Hardiman KM. Use of Accelerated Induction Strategy of Infliximab for Ulcerative Colitis in Hospitalized Patients at a Tertiary Care Center. Digestive diseases and sciences. 2020 Jun 1; 65(6):1800-1805.
  25. Rubenstein JH, Noureldin M, Tavakkoli A, Hur C, Omidvari AH, Waljee AK. Utilization of Surveillance Endoscopy for Barrett's Esophagus in Medicare Enrollees. Gastroenterology. 2020 Feb 1; 158(3):773-775.e1.
  26. Tapper EB, Parikh ND, Green PK, Berry K, Waljee AK, Moon AM, Ioannou GN. Reduced Incidence of Hepatic Encephalopathy and Higher Odds of Resolution Associated With Eradication of HCV Infection. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 2020 May 1; 18(5):1197-1206.e7.
  27. Cohen-Mekelburg S, Rosenblatt R, Wallace B, Shen N, Fortune B, Waljee AK, Saini S, Scherl E, Burakoff R, Unruh M. Inflammatory bowel disease readmissions are associated with utilization and comorbidity. The American journal of managed care. 2019 Oct 1; 25(10):474-481.
  28. Platt KD, Kurlander JE, Zikmund-Fisher BJ, Lipson R, Knaus M, Waljee AK, Saini SD. Rethinking the Re-Prep: Attitudes Toward Noninvasive Colorectal Cancer Screening Tests After Inadequate Bowel Preparation. The American journal of gastroenterology. 2019 Oct 1; 114(10):1685-1687.
  29. Wallace BI, Lin P, Kamdar N, Noureldin M, Hayward R, Fox DA, Curtis JR, Saag KG, Waljee AK. Patterns of glucocorticoid prescribing and provider-level variation in a commercially insured incident rheumatoid arthritis population: A retrospective cohort study. Seminars in Arthritis and Rheumatism. 2020 Apr 1; 50(2):228-236.
  30. Wallace BI, Wallace DM, Waljee AK, Clauw DJ. Evidence to support or guide glucocorticoid tapering in rheumatoid arthritis is lacking. Annals of The Rheumatic Diseases. 2019 Dec 1; 78(12):1733-1734.
  31. Ioannou GN, Beste LA, Green PK, Singal AG, Tapper EB, Waljee AK, Sterling RK, Feld JJ, Kaplan DE, Taddei TH, Berry K. Increased Risk for Hepatocellular Carcinoma Persists Up to 10 Years After HCV Eradication in Patients With Baseline Cirrhosis or High FIB-4 Scores. Gastroenterology. 2019 Nov 1; 157(5):1264-1278.e4.
  32. Kandavel P, Eder SJ, Newman NE, Waljee AK, Whitfield EP, Adler J. Mean Corpuscular Volume to White Blood Cell Ratio for Thiopurine Monitoring in Pediatric Inflammatory Bowel Disease. Journal of pediatric gastroenterology and nutrition. 2019 Jul 1; 69(1):88-94.
  33. Xu D, Chen VL, Steiner CA, Berinstein JA, Eswaran S, Waljee AK, Higgins PDR, Owyang C. Efficacy of Fecal Microbiota Transplantation in Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis. The American journal of gastroenterology. 2019 Jul 1; 114(7):1043-1050.
  34. Tavakkoli A, Singal AG, Waljee AK, Elmunzer BJ, Pruitt SL, McKey T, Rubenstein JH, Scheiman JM, Murphy CC. Racial Disparities and Trends in Pancreatic Cancer Incidence and Mortality in the United States. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 2020 Jan 1; 18(1):171-178.e10.
  35. Tavakkoli A, Singal AG, Waljee AK, Scheiman JM, Murphy CC, Pruitt SL, Xuan L, Kwon RS, Law RJ, Elta GH, Wright-Slaughter P, Valley TS, Kubiliun N, Nathan H, Rubenstein JH, Elmunzer BJ. Regional and racial variations in the utilization of endoscopic retrograde cholangiopancreatography among pancreatic cancer patients in the United States. Cancer medicine. 2019 Jul 1; 8(7):3420-3427.
  36. Stidham RW, Liu W, Bishu S, Rice MD, Higgins PDR, Zhu J, Nallamothu BK, Waljee AK. Performance of a Deep Learning Model vs Human Reviewers in Grading Endoscopic Disease Severity of Patients With Ulcerative Colitis. JAMA Network Open. 2019 May 3; 2(5):e193963.
  37. Waljee AK, Wallace BI, Cohen-Mekelburg S, Liu Y, Liu B, Sauder K, Stidham RW, Zhu J, Higgins PDR. Development and Validation of Machine Learning Models in Prediction of Remission in Patients With Moderate to Severe Crohn Disease. JAMA Network Open. 2019 May 3; 2(5):e193721.
  38. Wiitala WL, Vincent BM, Burns JA, Prescott HC, Waljee AK, Cohen GR, Iwashyna TJ. Variation in Laboratory Test Naming Conventions in EHRs Within and Between Hospitals: A Nationwide Longitudinal Study. Medical care. 2019 Apr 1; 57(4):e22-e27.
  39. Read AJ, Vijan S, Waljee AK, Saini SD. Increased Cost With Use of Brand-Name Bowel Preparation by Patients With Medicare Part D From 2013 to 2015. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 2019 Dec 1; 17(13):2806-2807.
  40. Cohen-Mekelburg S, Rosenblatt R, Gold S, Shen N, Fortune B, Waljee AK, Saini S, Scherl E, Burakoff R, Unruh M. Fragmented Care is Prevalent Among Inflammatory Bowel Disease Readmissions and is Associated With Worse Outcomes. The American journal of gastroenterology. 2019 Feb 1; 114(2):276-290.
  41. Konerman MA, Beste LA, Van T, Liu B, Zhang X, Zhu J, Saini SD, Su GL, Nallamothu BK, Ioannou GN, Waljee AK. Machine learning models to predict disease progression among veterans with hepatitis C virus. PLoS ONE. 2019 Jan 4; 14(1):e0208141.
  42. Lin KD, Chiu GF, Waljee AK, Owyang SY, El-Zaatari M, Bishu S, Grasberger H, Zhang M, Wu DC, Kao JY. Effects of Anti-Helicobacter pylori Therapy on Incidence of Autoimmune Diseases, Including Inflammatory Bowel Diseases. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 2019 Sep 1; 17(10):1991-1999.
  43. Singal AG, Tiro JA, Murphy CC, Marrero JA, McCallister K, Fullington H, Mejias C, Waljee AK, Pechero Bishop W, Santini NO, Halm EA. Mailed Outreach Invitations Significantly Improve HCC Surveillance Rates in Patients With Cirrhosis: A Randomized Clinical Trial. Hepatology (Baltimore, Md.). 2019 Jan 1; 69(1):121-130.
  44. Govani SM, Lipson R, Noureldin M, Wiitala W, Higgins PDR, Saini SD, Pugh JA, Velligan DI, Stidham RW, Waljee AK. Adalimumab persistence for inflammatory bowel disease in veteran and insured cohorts. The American journal of managed care. 2018 Dec 1; 24(12):e374-e379.
  45. Wallace BI, Waljee AK, Weissman A, Caverly TJ, Saini SD. Overuse of glucocorticoids in rheumatoid arthritis: a national survey of primary care physicians. Rheumatology advances in practice. 2018 Nov 23; 3(1):rky049.
  46. Berinstein JA, Steiner CA, Regal RE, Allen JI, Kinnucan JAR, Stidham RW, Waljee AK, Bishu S, Aldrich LB, Higgins PDR. Efficacy of Induction Therapy With High-Intensity Tofacitinib in 4 Patients With Acute Severe Ulcerative Colitis. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 2019 Apr 1; 17(5):988-990.e1.
  47. Setoodeh S, Liu L, Boukhar SA, Singal AG, Westerhoff M, Waljee AK, Ahmed T, Gopal P. The Clinical Significance of Crohn Disease Activity at Resection Margins. Archives of pathology & laboratory medicine. 2019 Apr 1; 143(4):505-509.
  48. Su GL, Glass L, Tapper EB, Van T, Waljee AK, Sales AE. Virtual Consultations Through the Veterans Administration SCAN-ECHO Project Improves Survival for Veterans With Liver Disease. Hepatology (Baltimore, Md.). 2018 Dec 1; 68(6):2317-2324.
  49. Cohen-Mekelburg S, Rosenblatt R, Gold S, Burakoff R, Waljee AK, Saini S, Schackman BR, Scherl E, Crawford C. The Impact of Opioid Epidemic Trends on Hospitalised Inflammatory Bowel Disease Patients. Journal of Crohn's & colitis. 2018 Aug 29; 12(9):1030-1035.
  50. Chang JW, Yeow RY, Waljee AK, Rubenstein JH. Systematic review and meta-regressions: management of eosinophilic esophagitis requires histologic assessment. Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus. 2018 Aug 1; 31(8).
  51. Grasberger H, Noureldin M, Kao TD, Adler J, Lee JM, Bishu S, El-Zaatari M, Kao JY, Waljee AK. Increased risk for inflammatory bowel disease in congenital hypothyroidism supports the existence of a shared susceptibility factor. Scientific reports. 2018 Jul 5; 8(1):10158.
  52. Goldsmith JR, Waljee AK, George T, Brown A, Choe HM, Noureldin M, Bernstein SJ, Higgins PDR. 5-ASA to sulfasalazine drug switch program in patients with ulcerative colitis. The American journal of managed care. 2018 Jul 1; 24(8 Spec No.):SP303-SP308.
  53. Waljee AK, Liu B, Sauder K, Zhu J, Govani SM, Stidham RW, Higgins PDR. Predicting Corticosteroid-Free Biologic Remission with Vedolizumab in Crohn's Disease. Inflammatory Bowel Diseases. 2018 May 18; 24(6):1185-1192.
  54. Waljee AK, Wiitala WL, Govani S, Stidham R, Saini S, Hou J, Feagins LA, Khan N, Good CB, Vijan S, Higgins PDR. Correction: Corticosteroid Use and Complications in a US Inflammatory Bowel Disease Cohort. PLoS ONE. 2018 May 9; 13(5):e0197341.
  55. Berinstein JA, Waljee AK, Stidham RW, Higgins PDR, Govani SM. The IBD SGI Diagnostic Test Is Frequently Used by Non-gastroenterologists to Screen for Inflammatory Bowel Disease. Inflammatory Bowel Diseases. 2018 Apr 23; 24(5):e18.
  56. Limsrivilai J, Rao K, Stidham RW, Govani SM, Waljee AK, Reinink A, Johnson L, Briggs E, Higgins PDR. Systemic Inflammatory Responses in Ulcerative Colitis Patients and Clostridium difficile Infection. Digestive diseases and sciences. 2018 Jul 1; 63(7):1801-1810.
  57. Govani SM, Higgins PDR, Rubenstein JH, Stidham RW, Waljee AK. CT utilization abruptly increases at age 18 among patients with inflammatory bowel diseases in the hospital. PLoS ONE. 2018 Mar 29; 13(3):e0195022.
  58. Tapper EB, Parikh ND, Waljee AK, Volk M, Carlozzi NE, Lok AS. Diagnosis of Minimal Hepatic Encephalopathy: A Systematic Review of Point-of-Care Diagnostic Tests. The American journal of gastroenterology. 2018 Apr 1; 113(4):529-538.
  59. Tzartzeva K, Obi J, Rich NE, Parikh ND, Marrero JA, Yopp A, Waljee AK, Singal AG. Surveillance Imaging and Alpha Fetoprotein for Early Detection of Hepatocellular Carcinoma in Patients With Cirrhosis: A Meta-analysis. Gastroenterology. 2018 May 1; 154(6):1706-1718.e1.
  60. Waljee AK, Liu B, Sauder K, Zhu J, Govani SM, Stidham RW, Higgins PDR. Predicting corticosteroid-free endoscopic remission with vedolizumab in ulcerative colitis. Alimentary pharmacology & therapeutics. 2018 Mar 1; 47(6):763-772.
  61. Wallace B, Saag KG, Curtis JR, Waljee AK. Just the FRAX: Management of Glucocorticoid-Induced Osteoporosis. Gastroenterology. 2018 Feb 1; 154(3):748-750.
  62. Rogers MAM, Lin P, Nallamothu BK, Kim C, Waljee AK. Longitudinal study of short-term corticosteroid use by working-age adults with diabetes mellitus: Risks and mitigating factors. Journal of diabetes. 2018 Jul 1; 10(7):546-555.
  63. Waljee AK, Sauder K, Patel A, Segar S, Zhang Y, Zhu J, Stidham RW, Balis U, Higgins PDR. Response to 'The end of the dosage of 6 Thioguanine nucleotides? Not so sure…'. Journal of Crohn's & colitis. 2018 Jan 5; 12(1):127.
  64. Rubenstein JH, Waljee AK, Dwamena B, Bergman J, Vieth M, Wani S. Yield of Higher-Grade Neoplasia in Barrett's Esophagus With Low-Grade Dysplasia Is Double in the First Year Following Diagnosis. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 2018 Sep 1; 16(9):1529-1530.
  65. Waljee AK, Lipson R, Wiitala WL, Zhang Y, Liu B, Zhu J, Wallace B, Govani SM, Stidham RW, Hayward R, Higgins PDR. Predicting Hospitalization and Outpatient Corticosteroid Use in Inflammatory Bowel Disease Patients Using Machine Learning. Inflammatory Bowel Diseases. 2017 Dec 19; 24(1):45-53.
  66. Govani SM, Noureldin M, Higgins PDR, Heisler M, Saini SD, Stidham RW, Waljee JF, Waljee AK. Defining an Optimal Adherence Threshold for Patients Taking Subcutaneous Anti-TNFs for Inflammatory Bowel Diseases. The American journal of gastroenterology. 2018 Feb 1; 113(2):276-282.
  67. Konerman MA, Lu D, Zhang Y, Thomson M, Zhu J, Verma A, Liu B, Talaat N, Balis U, Higgins PDR, Lok ASF, Waljee AK. Assessing risk of fibrosis progression and liver-related clinical outcomes among patients with both early stage and advanced chronic hepatitis C. PLoS ONE. 2017 Nov 6; 12(11):e0187344.
  68. Waljee AK, Yang Y, Wu GD. AAA IBD 2017: Methodologies to Collect and Analyze Clinical Data to Support Quality Improvement Initiatives Designed to Optimize the Care of Patients With IBD. Gastroenterology. 2017 Dec 1; 153(6):e1-e5.
  69. Glass LM, Waljee AK, McCurdy H, Su GL, Sales A. Specialty Care Access Network-Extension of Community Healthcare Outcomes Model Program for Liver Disease Improves Specialty Care Access. Digestive diseases and sciences. 2017 Dec 1; 62(12):3344-3349.
  70. Elmunzer BJ, Noureldin M, Morgan KA, Adams DB, Coté GA, Waljee AK. The Impact of Cholecystectomy After Endoscopic Sphincterotomy for Complicated Gallstone Disease. The American journal of gastroenterology. 2017 Oct 1; 112(10):1596-1602.
  71. Reutemann BA, Turkeltaub JA, Al-Hawary M, Waljee AK, Higgins PDR, Stidham RW. Endoscopic Balloon Dilation Size and Avoidance of Surgery in Stricturing Crohn's Disease. Inflammatory Bowel Diseases. 2017 Oct 1; 23(10):1803-1809.
  72. Rodriguez EA, Donath E, Waljee AK, Sussman DA. Value of Oral Proton Pump Inhibitors in Acute, Nonvariceal Upper Gastrointestinal Bleeding: A Network Meta-Analysis. Journal of clinical gastroenterology. 2017 Sep 1; 51(8):707-719.
  73. Waljee AK, Sauder K, Zhang Y, Zhu J, Higgins PDR. External Validation of a Thiopurine Monitoring Algorithm on the SONIC Clinical Trial Dataset. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 2018 Mar 1; 16(3):449-451.
  74. Feagins LA, Waljee A, Hou JK, Gu P, Kanjo S, Rudrapatna V, Cipher DJ, Govani S, Gaidos J. Incidence of and Predictors for Early Discontinuation of Biological Therapies in Veteran Patients with Inflammatory Bowel Disease. Inflammatory Bowel Diseases. 2017 Aug 1; 23(8):1434-1439.
  75. Saini SD, Waljee AK. Fool Me Thrice: The Evolving Story of Multiply Recurrent Clostridium difficile Infection. Annals of internal medicine. 2017 Aug 1; 167(3):202-203.
  76. Suresh SV, Govani SM, Waljee AK. Chromoendoscopy versus White Light Endoscopy: Does it Matter?. Gastroenterology. 2017 Sep 1; 153(3):864-866.
  77. Waljee AK, Sauder K, Patel A, Segar S, Liu B, Zhang Y, Zhu J, Stidham RW, Balis U, Higgins PDR. Machine Learning Algorithms for Objective Remission and Clinical Outcomes with Thiopurines. Journal of Crohn's & colitis. 2017 Jul 1; 11(7):801-810.
  78. Stidham RW, Waljee AK. Editorial: visceral fat as a predictor of post-operative recurrence of Crohn's disease. Alimentary pharmacology & therapeutics. 2017 Jun 1; 45(12):1551-1552.
  79. Waljee AK, Rogers MA, Lin P, Singal AG, Stein JD, Marks RM, Ayanian JZ, Nallamothu BK. Short term use of oral corticosteroids and related harms among adults in the United States: population based cohort study. BMJ (Clinical research ed.). 2017 Apr 12; 357:j1415.
  80. Kurlander JE, Kolbe M, Scheiman JM, Weissman A, Piette JD, Rubenstein JH, Waljee AK, Saini SD. The Right Idea for the Wrong Patient: Results of a National Survey on Stopping PPIs. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 2017 Sep 1; 15(9):1475-1476.
  81. Govani SM, Waljee AK. Therapeutic Drug Monitoring in IBD: Prospective Promise Unfulfilled. The American journal of gastroenterology. 2017 May 1; 112(5):670-672.
  82. Govani SM, Waljee AK, Kocher KE, Swoger JM, Saul M, Higgins PD. Validation of a tool predicting important findings on computed tomography among Crohn's disease patients. United European gastroenterology journal. 2017 Mar 1; 5(2):270-275.
  83. Limsrivilai J, Stidham RW, Govani SM, Waljee AK, Huang W, Higgins PD. Factors That Predict High Health Care Utilization and Costs for Patients With Inflammatory Bowel Diseases. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 2017 Mar 1; 15(3):385-392.e2.
  84. Piraka C, Saeed A, Waljee AK, Pillai A, Stidham R, Elmunzer BJ. Cold snare polypectomy for non-pedunculated colon polyps greater than 1?cm. Endoscopy international open. 2017 Mar 1; 5(3):E184-E189.
  85. Tapper EB, Beste L, Curry M, Bonder A, Waljee A, Saini S. Suboptimal Implementation of Evidence-based Therapy for Acute Variceal Hemorrhage: A Systematic Review of Observational Studies. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 2017 Sep 1; 15(9):1373-1381.e7.
  86. Kirk PS, Govani S, Borza T, Hollenbeck BK, Davis J, Shumway D, Waljee AK, Skolarus TA. Implications of Prostate Cancer Treatment in Men With Inflammatory Bowel Disease. Urology. 2017 Jun 1; 104:131-136.
  87. Kurlander JE, Sondhi AR, Waljee AK, Menees SB, Connell CM, Schoenfeld PS, Saini SD. How Efficacious Are Patient Education Interventions to Improve Bowel Preparation for Colonoscopy? A Systematic Review. PLoS ONE. 2016 Oct 14; 11(10):e0164442.
  88. Piper MS, Waljee AK, Stidham RW. Operate or Medicate: Understanding Surgical Risks in the Elderly with Inflammatory Bowel Disease. Gastroenterology. 2016 Nov 1; 151(5):1029-1030.
  89. Hou JK, Feagins LA, Waljee AK. Characteristics and Behavior of Elderly-onset Inflammatory Bowel Disease: A Multi-center US Study. Inflammatory Bowel Diseases. 2016 Sep 1; 22(9):2200-5.
  90. Govani SM, Wiitala WL, Stidham RW, Saini SD, Hou JK, Feagins LA, Sussman JB, Higgins PD, Waljee AK. Age Disparities in the Use of Steroid-sparing Therapy for Inflammatory Bowel Disease. Inflammatory Bowel Diseases. 2016 Aug 1; 22(8):1923-8.
  91. Stidham RW, Guentner AS, Ruma JL, Govani SM, Waljee AK, Higgins PD. Intestinal Dilation and Platelet:Albumin Ratio Are Predictors of Surgery in Stricturing Small Bowel Crohn's Disease. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 2016 Aug 1; 14(8):1112-1119.e2.
  92. Waljee AK, Wiitala WL, Govani S, Stidham R, Saini S, Hou J, Feagins LA, Khan N, Good CB, Vijan S, Higgins PD. Corticosteroid Use and Complications in a US Inflammatory Bowel Disease Cohort. PLoS ONE. 2016 Jun 23; 11(6):e0158017.
  93. Mellinger JL, Moser S, Welsh DE, Yosef MT, Van T, McCurdy H, Rakoski MO, Moseley RH, Glass L, Waljee AK, Volk ML, Sales A, Su GL. Access to Subspecialty Care And Survival Among Patients With Liver Disease. The American journal of gastroenterology. 2016 Jun 1; 111(6):838-44.
  94. Singal AG, Zhang P, Waljee AK, Ananthakrishnan L, Parikh ND, Sharma P, Barman P, Krishnamurthy V, Wang L, Wang SC, Su GL. Body Composition Features Predict Overall Survival in Patients With Hepatocellular Carcinoma. Clinical and translational gastroenterology. 2016 May 26; 7:e172.
  95. Patel J, Yopp A, Waljee AK, Singal AG. Development and Internal Validation of a Model for Early Detection of Hepatocellular Carcinoma in Patients With Cirrhosis. Journal of clinical gastroenterology. 2016 Feb 1; 50(2):175-9.
  96. Parikh ND, Waljee AK, Singal AG. Downstaging hepatocellular carcinoma: A systematic review and pooled analysis. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. 2015 Sep 1; 21(9):1142-52.
  97. Adams MA, Hosmer AE, Wamsteker EJ, Anderson MA, Elta GH, Kubiliun NM, Kwon RS, Piraka CR, Scheiman JM, Waljee AK, Hussain HK, Elmunzer BJ. Predicting the likelihood of a persistent bile duct stone in patients with suspected choledocholithiasis: accuracy of existing guidelines and the impact of laboratory trends. Gastrointestinal endoscopy. 2015 Jul 1; 82(1):88-93.
  98. Konerman MA, Zhang Y, Zhu J, Higgins PD, Lok AS, Waljee AK. Improvement of predictive models of risk of disease progression in chronic hepatitis C by incorporating longitudinal data. Hepatology (Baltimore, Md.). 2015 Jun 1; 61(6):1832-41.
  99. Stidham RW, Waljee AK, Day NM, Bergmans CL, Zahn KM, Higgins PD, Wang SC, Su GL. Body fat composition assessment using analytic morphomics predicts infectious complications after bowel resection in Crohn's disease. Inflammatory Bowel Diseases. 2015 Jun 1; 21(6):1306-13.
  100. Govani SM, Waljee AK, Stidham RW, Higgins PD. Increasing ultraviolet light exposure is associated with reduced mortality from Clostridium difficile infection. United European gastroenterology journal. 2015 Apr 1; 3(2):208-14.
  101. Elmunzer BJ, Singal AG, Sussman JB, Deshpande AR, Sussman DA, Conte ML, Dwamena BA, Rogers MA, Schoenfeld PS, Inadomi JM, Saini SD, Waljee AK. Comparing the effectiveness of competing tests for reducing colorectal cancer mortality: a network meta-analysis. Gastrointestinal endoscopy. 2015 Mar 1; 81(3):700-709.e3.
  102. Govani SM, Higgins PD, Stidham RW, Montain SJ, Waljee AK. Increased ultraviolet light exposure is associated with reduced risk of inpatient surgery among patients with Crohn's disease. Journal of Crohn's & colitis. 2015 Jan 1; 9(1):77-81.
  103. Govani SM, Guentner AS, Waljee AK, Higgins PD. Risk stratification of emergency department patients with Crohn's disease could reduce computed tomography use by nearly half. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 2014 Oct 1; 12(10):1702-7.e3.
  104. Saini SD, Waljee AK, Schoenfeld P, Kerr EA, Vijan S. The increasing importance of quality measures for trainees. Gastroenterology. 2014 Oct 1; 147(4):725-9.
  105. Krishnamurthy V, Zhang P, Ethiraj S, Enchakalody B, Waljee AK, Wang L, Wang SC, Su GL. Use of analytic morphomics of liver, spleen, and body composition to identify patients at risk for cirrhosis. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 2015 Feb 1; 13(2):360-368.e5.
  106. Hou JK, Tan M, Stidham RW, Colozzi J, Adams D, El-Serag H, Waljee AK. Accuracy of diagnostic codes for identifying patients with ulcerative colitis and Crohn's disease in the Veterans Affairs Health Care System. Digestive diseases and sciences. 2014 Oct 1; 59(10):2406-10.
  107. Stidham RW, Lee TC, Higgins PD, Deshpande AR, Sussman DA, Singal AG, Elmunzer BJ, Saini SD, Vijan S, Waljee AK. Systematic review with network meta-analysis: the efficacy of anti-TNF agents for the treatment of Crohn's disease. Alimentary pharmacology & therapeutics. 2014 Jun 1; 39(12):1349-62.
  108. Stidham RW, Lee TC, Higgins PD, Deshpande AR, Sussman DA, Singal AG, Elmunzer BJ, Saini SD, Vijan S, Waljee AK. Systematic review with network meta-analysis: the efficacy of anti-tumour necrosis factor-alpha agents for the treatment of ulcerative colitis. Alimentary pharmacology & therapeutics. 2014 Apr 1; 39(7):660-71.
  109. Singal AG, Manjunath H, Yopp AC, Beg MS, Marrero JA, Gopal P, Waljee AK. The effect of PNPLA3 on fibrosis progression and development of hepatocellular carcinoma: a meta-analysis. The American journal of gastroenterology. 2014 Mar 1; 109(3):325-34.
  110. Singal AG, Higgins PD, Waljee AK. A primer on effectiveness and efficacy trials. Clinical and translational gastroenterology. 2014 Jan 2; 5:e45.
  111. Waljee AK, Higgins PD, Singal AG. A primer on predictive models. Clinical and translational gastroenterology. 2014 Jan 2; 5:e44.
  112. Singal AG, Mukherjee A, Elmunzer BJ, Higgins PD, Lok AS, Zhu J, Marrero JA, Waljee AK. Machine learning algorithms outperform conventional regression models in predicting development of hepatocellular carcinoma. The American journal of gastroenterology. 2013 Nov 1; 108(11):1723-30.
  113. Gopal P, Yopp AC, Waljee AK, Chiang J, Nehra M, Kandunoori P, Singal AG. Factors that affect accuracy of a-fetoprotein test in detection of hepatocellular carcinoma in patients with cirrhosis. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 2014 May 1; 12(5):870-7.
  114. Singal AG, Waljee AK, Patel N, Chen EY, Tiro JA, Marrero JA, Yopp AC. Therapeutic delays lead to worse survival among patients with hepatocellular carcinoma. Journal of the National Comprehensive Cancer Network : JNCCN. 2013 Sep 1; 11(9):1101-8.
  115. Waljee AK, Stidham RW, Higgins PD, Vijan S, Saini SD. Point-counterpoint: Are we overtreating patients with mild ulcerative colitis? Journal of Crohn's & colitis. 2014 Jan 1; 8(1):80-4.
  116. Waljee AK, Mukherjee A, Singal AG, Zhang Y, Warren J, Balis U, Marrero J, Zhu J, Higgins PD. Comparison of imputation methods for missing laboratory data in medicine. BMJ open. 2013 Aug 1; 3(8).
  117. Elmunzer BJ, Hayward RA, Schoenfeld PS, Saini SD, Deshpande A, Waljee AK. Effect of flexible sigmoidoscopy-based screening on incidence and mortality of colorectal cancer: a systematic review and meta-analysis of randomized controlled trials. PLoS Medicine. 2013 Jun 4; 9(12):e1001352.
  118. Elmunzer BJ, Debenedet AT, Volk ML, Sonnenday CJ, Waljee AK, Fontana RJ, Oza AB, Singal A, Englesbe MJ, Scheiman JM. Clinical yield of diagnostic endoscopic retrograde cholangiopancreatography in orthotopic liver transplant recipients with suspected biliary complications. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. 2012 Dec 1; 18(12):1479-84.
  119. Cohen S, Saxena A, Waljee AK, Piraka C, Purdy J, Appelman H, McKenna B, Elmunzer BJ, Singal AG. Lymphocytic esophagitis: a diagnosis of increasing frequency. Journal of clinical gastroenterology. 2012 Nov 1; 46(10):828-32.
  120. Saini SD, Waljee AK, Higgins PD. Cost utility of inflammation-targeted therapy for patients with ulcerative colitis. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 2012 Oct 1; 10(10):1143-51.
Journal Other

  1. Wallace BI, Waljee AK. Burst Case Scenario: Why Shorter May Not Be Any Better When It Comes to Corticosteroids. [Editorial]. Annals of internal medicine. 2020 Sep 1; 173(5):390-391.
  2. Lu C, Wallace BI, Waljee AK, Fu W, Zhang Q, Liu Y. Comparative efficacy and safety of targeted DMARDs for active psoriatic arthritis during induction therapy: A systematic review and network meta-analysis. Seminars in Arthritis and Rheumatism. 2019 Dec 1; 49(3):381-388.
  3. Parikh ND, Zhang P, Singal AG, Derstine BA, Krishnamurthy V, Barman P, Waljee AK, Su GL. Body Composition Predicts Survival in Patients with Hepatocellular Carcinoma Treated with Transarterial Chemoembolization. [Letter to the Editor]. Cancer research and treatment : official journal of Korean Cancer Association. 2018 Apr 1; 50(2):530-537.
  4. Waljee AK, Rogers MAM, Nallamothu BK, all the authors. Authors' reply to Hamilton. BMJ (Clinical research ed.). 2017 May 24; 357:j2538.
  5. Govani SM, Waljee AK, Higgins PD. Reply: To PMID 24642110. Clinical Gastroenterology and Hepatology. 2015 Sep 1; 13(9):1707.
  6. Stidham RW, Waljee AK, Day NM, Bergmans CL, Zahn KM, Higgins PD, Wang SC, Su GL. Reply to Body Fat Composition Predicts Infectious Complications After Bowel Resection in Crohn's Disease. Inflammatory Bowel Diseases. 2015 Aug 1; 21(8):E19-20.
  7. Sondhi AR, Kurlander JE, Waljee AK, Saini SD. A telephone-based education program improves bowel preparation quality in patients undergoing outpatient colonoscopy. Gastroenterology. 2015 Mar 1; 148(3):657-8.
  8. Ayers K, Waljee AK, Saini SD. Short-term use of selective serotonin reuptake inhibitors increases risk of gastrointestinal bleeding in men with psychiatric diagnoses. Gastroenterology. 2014 Nov 1; 147(5):1173-4.
  9. Yopp A, Waljee A, Singal AG. Does surveillance for hepatocellular carcinoma benefit patients with compensated cirrhosis? Gastroenterology. 2014 Oct 1; 147(4):935-6.
  10. Corsello PM, Micic D, Rao K, Waljee AK. Challenges in the diagnosis of Clostridium difficile infection. Gastroenterology. 2014 Jun 1; 146(7):1820-2.
  11. Naveed M, Waljee AK, Singal AG. Predictive models for hepatocellular carcinoma. Gastroenterology. 2014 May 1; 146(5):1420-1.
  12. Patel A, Max JB, Singal AG, Waljee AK. Herpes zoster and IBD: are we being brash about a rash? Gastroenterology. 2014 Feb 1; 146(2):576-7.
  13. Elmunzer BJ, Waljee AK. Can rectal NSAIDs replace prophylactic pancreatic stent placement for the prevention of post-ERCP pancreatitis? Gastroenterology. 2014 Jan 1; 146(1):313-5; discussion 315.
  14. Govani SM, Waljee AK, Higgins PD. Anti-adhesion therapies and the rule of 3 for rare events. The American journal of gastroenterology. 2013 Dec 1; 108(12):1831-2.
  15. Lee T, Singal AG, Sussman J, Waljee AK. At the "heart" of inflammatory bowel diseases. Gastroenterology. 2013 Dec 1; 145(6):1486-8.
  16. Max JB, Stidham R, Su GL, Waljee AK. Obesity and IBD: are we tipping the scales toward an epidemic? Gastroenterology. 2013 Aug 1; 145(2):478-9.
  17. Max JB, Singal AG, Waljee AK. Stepping out with IBD: can we take the road less travelled? Gastroenterology. 2012 Aug 1; 143(2):498-9.
Conference Presentations

  1. Chen D, Waljee AK, Govani SM, Higgins PD, Stidham RW. Long-Term Persistence of Methotrexate Use is Lower Than Azathioprine in the Treatment of Inflammatory Bowel Disease. Paper presented at: Digestive Disease Week Annual Conference; 2016 May 24; San Diego, CA.
  2. Adler J, Govani SM, Dong S, Waljee AK, Higgins PD, Dombkowski KJ. Perianal Crohn's Disease is Associated with Low Ultraviolet Light Exposure in a National Pediatric Inflammatory Bowel Disease Quality Improvement Collaborative. Paper presented at: Digestive Disease Week Annual Conference; 2016 May 23; San Diego, CA.
  3. Govani SM, Waljee AK, Stidham RW, Higgins P, Hardiman K. Accelerated Dosing of Infliximab Prevents Colectomy Within 90 Days in Only Half of Patients With Severe Ulcerative Colitis. Paper presented at: Digestive Disease Week Annual Conference; 2016 May 23; San Diego, CA.
  4. Waljee AK. Cost-Effectiveness of Biologics for Inflammatory Bowel Disease (Clinical Symposium). Paper presented at: Digestive Disease Week Annual Conference; 2016 May 23; San Diego, CA.
  5. Berinstein J, Higgins PD, Waljee AK, Stidham RW, Govani SM. The SGI Panel Is Frequently Used by Non-Gastroenterologists to Diagnose Inflammatory Bowel Disease. Poster session presented at: Digestive Disease Week Annual Conference; 2016 May 22; San Diego, CA.
  6. Govani SM, Higgins PD, Rubenstein J, Stidham RW, Waljee J, Waljee AK. Increases at Age 18 among Patients with Inflammatory Bowel Diseases, A Nationwide Analysis of the Insured. Paper presented at: Digestive Disease Week Annual Conference; 2016 May 22; San Diego, CA.
  7. Panara AJ, Zhang HC, Waljee AK, Gaidos J, Feagins LA, Thrift AP, El-Serag HB, Hou J. Presence of Colonic Dysplasia prior to Colorectal Cancer Diagnosis is Associated with Early Stage Cancer among Patients with Inflammatory Bowel Disease: A National Cohort Study. Poster session presented at: Digestive Disease Week Annual Conference; 2016 May 22; San Diego, CA.
  8. Piper MS, Kurlander J, Zikmund-Fisher BJ, Maratt JK, Waljee AK, Saini SD. Patients' Willingness To Share Limited Endoscopic Resources: Results Of A Large Regional Survey. Poster session presented at: Digestive Disease Week Annual Conference; 2016 May 22; San Diego, CA.
  9. Thakur ER, Waljee AK, Gaidos J, Feagins LA, Govani SM, Sansgiry S, Kramer JR, Dindo L, El-Serag HB, Hou JK. The Incidence and Prevalence of Anxiety, Depression, and PTSD Among a National Cohort of United States Veterans With Inflammatory Bowel Disease. Poster session presented at: Digestive Disease Week Annual Conference; 2016 May 22; San Diego, CA.
  10. Zhang HC, Panara A, Thrift A, El-Serag H, Hou J, Waljee AK. Retrospective Study Demonstrating Earlier Diagnosis of Colorectal Cancer in African Americans Compared to Caucasians after IBD Diagnosis in VA Patients. Poster session presented at: Digestive Disease Week Annual Conference; 2016 May 22; San Diego, CA.
  11. Kurlander JE, Sondhi AR, Waljee AK, Mennes SB, Schoenfeld P, Saini SD. A Systematic Review of Patient Education Interventions To Improve Colonoscopy Bowel Preparation. Poster session presented at: VA HSR&D / QUERI National Meeting; 2015 Jul 9; Philadelphia, PA.
  12. Govani SM, Wiitala WL, Stidham RW, Saini SD, Hou JK, Feagins LA, Higgins P, Waljee AK. Factors Associated with the Use of Corticosteroid-Sparing Medications among Elderly Veterans with Inflammatory Bowel Disease. Poster session presented at: Digestive Disease Week Annual Conference; 2015 May 19; Washington, DC.
  13. Sondhi AR, Kurlander JE, Waljee AK, Menees SB, Schoenfeld PS, Saini SD. A Systematic Review of Patient-Oriented Educational Interventions To Improve Quality of Pre-Colonoscopy Bowel Preparation. Poster session presented at: Digestive Disease Week Annual Conference; 2015 May 17; Washington, DC.
  14. Chen DD, Waljee AK, Govani SM, Higgins P, Stidham RW. Incident Infectious and Malignant Adverse Event Risk is Lower Using Methotrexate Compared to Thiopurines in Crohn’s disease. Poster session presented at: Digestive Disease Week Annual Conference; 2015 May 16; Washington, DC.
  15. Singal AG, Zhang P, Lakshmi A, Waljee AK, Sharma P, Barman P, Krishnamurthy V, Wang L, Wang SC, Su GL. Analytic morphomics predicts overall survival in patients with hepatocellular carcinoma. Poster session presented at: Digestive Disease Week Annual Conference; 2015 May 16; Washington, DC.
  16. Stidham RK, Ruma JA, Enchakalody B, Waljee AK, Govani SM, Higgins P, Su GL. Quantitative Visceral Fat Findings Using Analytic Morphomics are Associated with Future Surgical Bowel Resection in Stricturing Crohn’s Disease. Poster session presented at: Digestive Disease Week Annual Conference; 2015 May 16; Washington, DC.
  17. Govani S, Waljee AK, Swoger J, Saul M, Higgins P. Stop the Scanners! External Validation of Algorithms Predicting Complications in Patients with Crohn’s Disease Presenting to the Emergency Department. Poster session presented at: Crohn's and Colitis Foundation of America Advances In Inflammatory Bowel Diseases Clinical and Research Conference; 2014 Dec 6; Orlando, FL.
  18. Hou Ja, Feagins L, Waljee AK. Characteristics and Behavior of Elderly-Onset Inflammatory Bowel Disease: A Multi-Center U.S. Study. Poster session presented at: Crohn's and Colitis Foundation of America Advances In Inflammatory Bowel Diseases Clinical and Research Conference; 2014 Dec 5; Orlando, FL.
  19. Stidham R, Dillman J, Waljee AK. Ultrasound stiffness imaging of bowel wall to predict medication failure in obstructive Crohn's disease. Poster session presented at: Crohn's and Colitis Foundation of America Advances In Inflammatory Bowel Diseases Clinical and Research Conference; 2014 Dec 5; Orlando, FL.
  20. Govani SM, Higgins PD, Stidham RW, Waljee AK. Increased Ultraviolet Light Exposure Protects against Surgery in Patients with Crohn's Disease. Poster session presented at: Digestive Disease Week Annual Meeting; 2014 May 6; Chicago, IL.
  21. Hou J, Shakhatreh MH, Richardson P, Waljee AK, Khan N, El-Serag H. Dysplasia Detection in Surveillance Colonoscopy in a National Cohort of Veterans with Inflammatory Bowel Disease. Poster session presented at: Digestive Disease Week Annual Meeting; 2014 May 6; Chicago, IL.
  22. Kolbe MS, Waljee AK, Weissman A, Saini SD. The Impact of Potential PPI Harms on Self-Reported PPI Prescribing: A National Survey of Physicians. Poster session presented at: Digestive Disease Week Annual Meeting; 2014 May 5; Chicago, IL.
  23. Meier A, Yopp A, Kandunoori P, Waljee AK, Marrero JA, Singal AG. Poor Quality of Life in Patients with Hepatocellular Carcinoma Associated with Worse Prognosis. Poster session presented at: Digestive Disease Week Annual Meeting; 2014 May 5; Chicago, IL.
  24. Govani SM, Waljee AK, Stidham RW, Higgins PD. Infliximab Reduces 90 Day Colectomy Rate versus Cyclosporine for Acute Severe Ulcerative Colitis. Poster session presented at: Digestive Disease Week Annual Meeting; 2014 May 4; Chicago, IL.
  25. Giovani SM, Waljee AK, Stidham RW, Higgins PD. Increased Ultraviolet Light Exposure Protects against Inpatient Mortality in Patients with a Primary Diagnosis of Clostridium difficile Infection. Poster session presented at: Digestive Disease Week Annual Meeting; 2014 May 3; Chicago, IL.
  26. Stidham RW, Lee T, Higgins PD, Deshpande AR, Sussman DA, Singal AG, Elmunzer BJ, Saini SD, Vijan S, Waljee AK. Systematic review with network meta-analysis: the efficacy of anti-TNF agents for the treatment of Crohn's disease. Poster session presented at: Digestive Disease Week Annual Meeting; 2014 May 3; Chicago, IL.
  27. Hou J, Tan M, Mimi T, Stidham R, Colozzi J, Adams D, El-Serag HB, Waljee A. Accuracy of Administrative Codes for Identifying Patients with Ulcerative Colitis and Crohn’s Disease in the Veterans Affairs Health Care Systems (VAHCS). Poster session presented at: Digestive Disease Week Annual Meeting; 2013 May 20; Orlando, FL.
  28. Stidham RW, Guenter A, Waljee AK. Small bowel dilation and platelet-to-albumin ratio predict the likelihood of surgery in Crohn's disease. Poster session presented at: Digestive Disease Week Annual Meeting; 2013 May 20; Orlando, FL.
  29. Guentner A, Govani SM, Waljee AK, Higgins PD. Increasing CT scan use and higher admission rates of Crohn's disease at a tertiary care center compared to national rates. Poster session presented at: Digestive Disease Week Annual Meeting; 2013 May 19; Orlando, FL.
  30. Stidham RW, Waljee AK, Day N, Higgins PD, Bergmans CL, Zahn KM, Wang SC, Su GL. Apples are higher risk than pears: subcutaneous fat measurement using analytic morphomics and the risk of infectious complications in abdominal surgeries for Crohn's disease. Paper presented at: Digestive Disease Week Annual Meeting; 2013 May 19; Orlando, FL.
  31. Giovani SM, guentner A, Waljee AK, Higgins PD. Automable Algorithms to Identify Crohn's Disease Patients with Low Likelihood of a Significant CT Finding the Emergency Department. Poster session presented at: Digestive Disease Week Annual Meeting; 2013 May 18; Orlando, FL.


DRA: Autoimmunity, Allergy, and Inflammation
DRE: Prevention, Prognosis, Treatment - Preclinical
Keywords: none
MeSH Terms: none

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