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Health Services Research & Development

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HERC Health Economics Seminar

The Power of Observational Data to Compare Treatments for Type 2 Diabetes on Long-Term Outcomes


by Julia Prentice, PhD
Seminar date: 4/16/2014

Description: Type 2 diabetes is a significant cause of morbidity and mortality. The progressive nature of the disease often requires a sequence of medications. With over 12 classes of glucose-lowering medications approved it can be difficult for providers and patients to choose the most effective medications. Evidence on medication effectiveness is often based on randomized clinical trials that focus on short-term outcomes due to their short-time frames. This seminar will explain how quasi-experimental methods can be applied to observational studies to examine the long-term outcomes of different medications. Specific objectives include: 1) Compare the strengths and weaknesses of randomized clinical trails to observational studies; 2) Describe the instrumental variable methods that can test causal effects of medications on long-term health outcomes; 3) Compare commonly used Type 2 diabetes on long-term outcomes and 4) Explore policy implications for the VA national formulary and treatment implications for patients and providers.

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