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Caplan AM, Caplan L. The GRADE Method. Rheumatic diseases clinics of North America. 2022 Aug 1; 48(3):589-599.
The Grades of Recommendation, Assessment, Development and Evaluation (GRADE) approach has emerged as an extremely common method for rating quality of a body of evidence in systematic reviews and for converting this evidence into guidelines. The American College of Rheumatology has effectively adopted this method, with minor modifications, for recent guidelines. This article reviews some of the basic principles of the GRADE approach and provides additional resources for use of GRADE.