Implementation of a Cardiovascular Implantable Electronic Device Heart Failure Prediction Tool-Guided Management Pathway.

Kratka, Rohrbach, Puckett, Rotering, Raitt, Whooley, Dhruva. Implementation of a Cardiovascular Implantable Electronic Device Heart Failure Prediction Tool-Guided Management Pathway. The American journal of cardiology. 2024 Dec 15; 233:74-82, DOI: 10.1016/j.amjcard.2024.09.030.

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Abstract:

Cardiovascular implantable electronic devices (CIEDs) monitor physiologic variables that could identify subacute heart failure (HF) decompensation and impending HF hospitalization. One such algorithm uses measurements from the previous 30 days of CIED remote monitoring data to predict low-, medium-, or high-probability of HF hospitalization in the next 30 days. We sought to understand how to prospectively implement the use of such algorithms in routine HF care. From January 18, 2024 to April 19, 2024, HF risk categories were predicted from scheduled remote transmissions every 30 days and from unscheduled transmissions for all patients at 2 distinct cardiology clinics. Clinicians contacted and assessed patients at high risk regarding symptoms and then provided an empiric 3-day diuretic intervention (initiation or dose augmentation), adjusted guideline-directed medical therapy, or performed other clinical action as appropriate. Among 358 patients with 1,140 remote transmissions, 72 (20%) had ≥1 transmission categorized as high-risk. The mean patient age was 72.8 years, 346 (97%) were male, and 221 (62%) had a pre-existing diagnosis of HF. Of these 72 patients, 67 (93%) were successfully contacted, 34 (51%) had no HF symptoms, 24 (36%) had mild to moderate symptoms, and 2 (3%) had severe symptoms. A total of 46 patients (69%) had clinical action taken, including 28 (42%) with a diuretic intervention and 12 (18%) with guideline-directed medical therapy augmented. In this implementation study, clinicians contacted and assessed nearly all patients at high risk for HF decompensation based on CIED remote monitoring data and intervened in more than 2/3s. A randomized clinical trial is needed to determine whether this algorithm and subsequent intervention improves clinical outcomes.