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Physical activity and diet just-in-time adaptive intervention to reduce blood pressure: a randomized controlled trial.

Dorsch MP, Golbus JR, Stevens R, Trumpower B, Basu T, Luff E, Warden K, Giacalone M, Bailey S, Rubick GV, Mishra S, Klasnja P, Klasnja P, Newman MW, Newman MW, Skolarus LE, Skolarus LE, Nallamothu BK, Nallamothu BK, Nallamothu BK. Physical activity and diet just-in-time adaptive intervention to reduce blood pressure: a randomized controlled trial. NPJ digital medicine. 2025 Jul 14; 8(1):438, DOI: 10.1038/s41746-025-01844-3.

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Abstract:

Mobile health interventions for behavioral change require large-scale studies to ensure their clinical benefits. We conducted a randomized controlled trial of patients with hypertension to assess the myBPmyLife application in promoting physical activity and lower-sodium foods to lower systolic blood pressure (SBP). 602 participants were randomly assigned to either a control group or an intervention group that received the myBPmyLife application. For the primary outcome, change in SBP over 6 months was -5.2?mmHg in the intervention and -5.7?mmHg in the control group (p? = 0.76). For secondary outcomes, the intervention group increased their daily step count by 170 steps, while the control group decreased by 319 steps (p? = 0.040). Sodium intake decreased by 1145?mg in the intervention and 860?mg in the control group (p? = 0.002). The myBPmyLife application did not reduce SBP over 6 months in hypertension patients despite increasing step counts and lowering sodium intake. ClinicalTrials.gov registration: NCT05154929, 12/2021.




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