Introducing the suicide prevention trials database: A publicly available data repository of suicide prevention studies.

O'Neil ME, Veazie S, Krushnic D, Hannon S, Baker-Robinson W, Adams J, Clauss K, Constans J, Hamblen JL, Somohano VC, Denneson LM. Introducing the suicide prevention trials database: A publicly available data repository of suicide prevention studies. Suicide & Life-Threatening Behavior. 2025 Feb 1; 55(1):e13152, DOI: 10.1111/sltb.13152.

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Abstract:

BACKGROUND: Healthcare, research, policy, and legislative stakeholders need timely, accurate, and detailed information on the effectiveness and potential harms of suicide prevention approaches. We created the Suicide Prevention Trials Database (SPTD) to provide a centralized, publicly accessible, detailed database of harmonized study-level suicide prevention clinical trial data. METHODS: We searched for randomized controlled trials (RCTs) of suicide prevention published from 1980 to 2023. Over 300 data variables were extracted from each RCT. RESULTS: We identified a total of 140 unique RCTs in 180 articles. Most of the included RCTs compared two treatment arms (92%), and the remainder compared three arms (88%). Nearly half of the RCTs reported on Behavioral Interventions (49%), followed by Care Management, Follow-up, or Monitoring (16%). Typically, the comparator condition was Treatment as Usual (53%). Interventions were most often delivered in person (61%) in an individual format (79%). CONCLUSIONS: The SPTD provides efficient, accurate, up-to-date access to a comprehensive suicide prevention trials database, which can be utilized by a range of stakeholders. It can reduce the time required for high-quality systematic reviews and provides researchers, administrators, and funders with current data on the state of the literature.