ASCO State of Cancer Care in America Special Report 2025: Access to Cancer Clinical Trials in the United States.

Balogh EP, Levit LA, Unger JM, Accordino MK, Chism DD, Kirkwood MK, Parsons HM, Patel MI, Peppercorn JM, Polite BN, Sedrak MS, Sharma P, Subbiah IM, Temel JS, Yabroff KR, Osarogiagbon RU. ASCO State of Cancer Care in America Special Report 2025: Access to Cancer Clinical Trials in the United States. JCO oncology practice. 2025 Oct 6; OP2500233, DOI: 10.1200/OP-25-00233.

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Abstract:

Improving patient access to cancer clinical trials is a fundamental ASCO priority because clinical cancer research is the essential link transforming biomedical discoveries into meaningful progress in cancer care and patient outcomes. Today''s standard of care emerged from yesterday''s clinical trials. However, numerous barriers continue to threaten patient access to cancer clinical trials. This Special Report describes the essential role clinical trials play in improving cancer care and patient outcomes, current challenges in the design and conduct of clinical trials, and steps taken by ASCO to make clinical trials more accessible, patient-centered, and embedded within the communities where people live.