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Drug toxicity, HIV progression, or comorbidity of aging: does tipranavir use increase the risk of intracranial hemorrhage?

Justice AC, Zingmond DS, Gordon KS, Fultz SL, Goulet JL, King JT, Bravata DM, Valdez H, Kraft M, Mattocks KM, Veterans Aging Cohort Study Project Team. Drug toxicity, HIV progression, or comorbidity of aging: does tipranavir use increase the risk of intracranial hemorrhage? Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2008 Nov 1; 47(9):1226-30.

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Abstract:

The US Food and Drug Administration has issued a warning that tipranavir may be associated with increased risk of intracranial hemorrhage. We studied 2 large cohorts to estimate the background rate of intracranial hemorrhage and compared it with rates reported among persons who had been exposed to tipranavir.




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