Benign prostatic hyperplasia (BPH) causes urinary hesitancy and intermittency, weak urine stream,
nocturia, frequency, urgency, and the sensation of incomplete bladder emptying. These symptoms,
collectively called "lower urinary tract symptoms," or LUTS, can significantly reduce quality of life.
Depending upon the severity of sypmtoms, men may be managed without pharmacotherapy, or they may
require medical treatments of drugs from two main classes. This Evidence Synthesis Report addresses
the following questions about treatment for BPH:
For patients with BPH, what are the comparative benefits, harms, and efficacy of
combination therapy with a 5-alpha-reductase inhibitor plus an alpha blocker, versus either treatment alone?
What are the comparative efficacy and harms of alpha-1-adrenergic antagonists?
Are there subgroups of patients based on demographics (age, racial groups), other
medications, or co-morbidities for which one treatment is more effective or associated with fewer adverse events?