Creation of a Quality Payment Program Measure for Mismatch Repair or Microsatellite Instability Biomarker Testing Status in Colorectal, Endometrial, Gastroesophageal, or Small Bowel Carcinoma.

Bocsi GT, Laudadio J, Jain R, Eakin SM, Bhalla A, Rosenberg JA, Maratt JK, Kupfer SS, Leiman DA, Cardona DM. Creation of a Quality Payment Program Measure for Mismatch Repair or Microsatellite Instability Biomarker Testing Status in Colorectal, Endometrial, Gastroesophageal, or Small Bowel Carcinoma. Archives of pathology & laboratory medicine. 2023 Sep 14.

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Abstract:

CONTEXT.—: Quality measures that are supported by evidence-based clinical practice guidelines are preferred for assessing the quality of pathologists'' practices. Careful testing of a measure ensures that scores obtained by that measure reflect the quality of a pathologist''s practice. OBJECTIVE.—: To specify a new quality measure and to demonstrate through testing that it is suitable for measuring pathologists'' appropriate incorporation of information regarding microsatellite instability (MSI) and/or mismatch repair (MMR) status in pathology reports for colorectal, endometrial, gastroesophageal, and small bowel carcinoma. DESIGN.—: The College of American Pathologists collaborated with the American Gastroenterological Association to specify and test the new measure. Face validity testing was used to investigate the validity of the measure. Feasibility testing was conducted to understand if data elements required by the measure specification were readily accessible. Signal-to-noise analysis was used to characterize the measure''s reliability. RESULTS.—: Guideline recommendations for MSI and/or MMR testing supported specifications for the measure. Face validity testing indicated that the measure could distinguish the quality of care provided. Data elements required by the measure specification were found to be accessible, which supported the measure''s feasibility. Reliability testing showed that differences in measure score were attributable to real differences in performance rather than random variation in scoring. CONCLUSIONS.—: The Mismatch Repair or Microsatellite Instability Biomarker Testing Status in Colorectal Carcinoma, Endometrial, Gastroesophageal, or Small Bowel Carcinoma measure was appropriately specified, and testing demonstrated that it is well suited for characterizing the quality of pathologists'' communication of MMR and/or MSI status.