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Spotlight on Evidence Synthesis Program

Mapping the Evidence: Sex and Gender Differences in Treatments for Depression, Diabetes, and Chronic Pain.


by Wei Denise Duan-Porter, MD, PhD ; Karen Goldstein, MD, MSPH ; John Williams, Jr., MD, MHSc
Seminar date: 12/9/2015

Description: Of 313 eligible systematic reviews examining the conditions of interest, less than 10% reported sex or gender differences in treatment effectiveness or risk for adverse effects. These differences were most often addressed for medications treating depression or diabetes. Review of a subset of primary randomized trial data showed that few had sample sizes large enough to examine moderator effects, and only 14% reported analysis of interactions between sex and intervention vs. control group. Intended audience: Researchers, clinicians, and operations leadership and staff—anyone who is interested in women’s health.

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