• Krebs EE, Nelson DB. Improving Research Design in Long-Term Opioid Management-Reply. JAMA internal medicine. 2025 Sep 1; 185(9):1170-1171, DOI: 10.1001/jamainternmed.2025.1724.
• Barrett AK, Sandbrink F, Mardian A, Oliva EM, Torrise V, Zhang R, Bukowski K, Burk M, Cunningham FE. Medication Use Evaluation of High-Dose Long-Term Opioid De-prescribing in Multiple Veterans Affairs Medical Centers. Journal of general internal medicine. 2022 Dec 1; 37(16):4037-4046.
• Ervin-Sikhondze BA, Moser SE, Pierce J, Dickens JR, Lagisetty PA, Urquhart AG, Hallstrom BR, Brummett CM, McAfee J. Reasons for Preoperative Opioid Use Are Associated with Persistent Use following Surgery Among Patients Undergoing Total Knee and Hip Arthroplasty. Pain medicine (Malden, Mass.). 2022 Jan 3; 23(1):19-28.
• Bushey MA, Slaven J, Outcalt SD, Kroenke K, Kempf C, Froman A, Sargent C, Baecher B, Zillich A, Damush TM, Saha C, French DD, Bair MJ. Design and methods of the Care Management for the Effective Use of Opioids (CAMEO) trial. Contemporary clinical trials. 2021 Jul 1; 106:106456.
• Lagisetty P, Bohnert A, Goesling J, Hu HM, Travis B, Lagisetty K, Brummett CM, Englesbe MJ, Waljee J. Care Coordination for Patients on Chronic Opioid Therapy Following Surgery: A Cohort Study. Annals of surgery. 2020 Aug 1; 272(2):304-310.

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• Strategies VA Clinicians Use to Structure Difficult Conversations Regarding Opioid Prescribing
  This study aimed to identify and describe clinicians’ strategies for managing prescription opioid misuse and aberrant behaviors among patients prescribed long-term opioid therapy (LTOT) for chronic pain. Interview results identified challenges faced by clinicians in navigating conversations about opioid management, stemming from patient dissatisfaction and clinician ambivalence about enacting guid...
  
  Date: July 1, 2019
• JGIM Supplement Highlights VA’s Partnered Research
  In this JGIM Supplement, 12 articles describe partnered research at various stages – from conceptualizing partnered research to examples of findings borne from bi-directional collaborations with investigators and leaders from clinical operations. These articles cover a wide range of topics highly relevant to VA policy and practice, including performance measure implementation on provider motivatio...
  
  Date: November 1, 2014

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Other Resources

• Learn more about VA HSR’s State of the Art conferences on opioid safety and non-pharmacological approaches to chronic musculoskeletal pain management.
• Learn more about the Quality Enhancement Research Initiative’s IMPROVE project, which focuses on integrating pain support in primary care in order to decrease the number of Veterans using opioid therapy for pain management.
• Visit the VA Office of Research & Development’s Substance Use Disorders (SUD) topic page for information about milestones in SUD research across all VA research services.