Evidence Synthesis Program (ESP) Center
Portland VA Health Care System
Devan Kansagara, MD, MCR, Director
Kondo K, Ayers CK, Chopra P, Antick J, Kansagara D. End Stage Renal Disease and Depression: A Systematic Review. Washington, DC: Evidence Synthesis Program, Health Services Research and Development Service, Office of Research and Development, Department of Veterans Affairs. VA ESP Project #05-225; 2020.
We conducted a systematic review to evaluate the performance characteristics of screening tools for depression in Veterans with end-stage renal disease (ESRD), and to better understand the impact, benefits, and harms of depression screening and subsequent treatment for depression.
Key Question 1. What are the performance characteristics of screening tools for depression in patients with ESRD?
Key Question 2. What is the impact of screening for depression in patients with ESRD on intermediate and/or patient outcomes?
Key Question 3. What is the effectiveness of depression treatment in patients with ESRD and depression?
Key Question 4. In patients with ESRD and depression, what are the potential harms of screening and treatment?
Key Question 5. Do the benefits or harms of screening differ by subpopulations?
Key Question 6. Do the benefits or harms of treatment differ by subpopulations?