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End-stage Renal Disease and Depression: A Systematic Review

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End-stage Renal Disease and Depression: A Systematic Review

Prepared by:
Evidence Synthesis Program (ESP) Center
Portland VA Health Care System Portland, OR
Devan Kansagara, MD, MCR, Director

Recommended citation:
Kondo K, Ayers CK, Chopra P, Antick J, Kansagara D. End Stage Renal Disease and Depression: A Systematic Review. Washington, DC: Evidence Synthesis Program, Health Services Research and Development Service, Office of Research and Development, Department of Veterans Affairs. VA ESP Project #05-225; 2020.



Download PDF: Complete Report, Executive Summary, Report, Appendices

Aim

We conducted a systematic review to evaluate the performance characteristics of screening tools for depression in Veterans with end-stage renal disease (ESRD), and to better understand the impact, benefits, and harms of depression screening and subsequent treatment for depression.

Key Questions

Key Question 1. What are the performance characteristics of screening tools for depression in patients with ESRD?

Key Question 2. What is the impact of screening for depression in patients with ESRD on intermediate and/or patient outcomes?

Key Question 3. What is the effectiveness of depression treatment in patients with ESRD and depression?

Key Question 4. In patients with ESRD and depression, what are the potential harms of screening and treatment?

Key Question 5. Do the benefits or harms of screening differ by subpopulations?

Key Question 6. Do the benefits or harms of treatment differ by subpopulations?

See also

Kondo K, Antick J, Ayers C, Kansagara D, and Chopra P. Depression Screening Tools for Patients with Kidney Failure. Clinical Journal of the American Society of Nephrology. Published online November 17, 2020. DOI: https://doi.org/10.2215/CJN.05540420.

Jones J. Depression: A Side Effect of CKD. Clinical Journal of the American Society of Nephrology. Published online November 17, 2020. DOI: https://doi.org/10.2215/CJN.16411020

Chopra P, Ayers C, Antick J, Kansagara D, and Kondo K. The Effectiveness of Depression Treatment for Adults with End-Stage Kidney Disease: A Systematic Review. Kidney360. Published online January 11, 2021. DOI: 10.34067/KID.0003142020.

End-stage Renal Disease and Depression: A Systematic Review (Management eBrief)


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