Age-related macular degeneration (AMD) is the leading cause of irreversible vision loss in the
developed world. In 2004, AMD affected 1.75 million persons in the United States, a number
that is expected to rise to nearly 3 million by 2020 due to the aging of the population.
The severity of macular degeneration ranges from Category 1 (least severe) to Category 4 (most
severe), and ï¿½advanced AMDï¿½ is defined as having geographic atrophy involving the center of
the macula or features of choroidal neovascularization.
Observational studies suggest that people with dietary intakes higher in various carotenoids,
antioxidants and omega-3 fatty acids have a lower risk of developing AMD. This has led to
several supplementation trials designed to examine the ability of nutritional supplement with
carotenoids, antioxidants, or omega-3 fatty acids to prevent the progression of AMD.
Our report focuses on the evidence documenting the potential benefits and harms of certain
dietary supplements in patients with AMD. We conducted a systematic review of published
literature to address the following key questions: