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Engaging Patients to Optimize Medication Adherence

Zullig LL, Bosworth HB. Engaging Patients to Optimize Medication Adherence. NEJM Catalyst [Internet]. 2017 May 14: Available from:


Medication non-adherence has important health consequences, ranging from decreased quality of life and poorly managed symptoms to death. But the implications of medication non-adherence extend beyond the individual; non-adherence is also associated with significant societal costs. Upwards of $300 billion of avoidable health care costs have been attributed to medication non-adherence annually in the U.S., comprising up to 10% of total health care costs. In this article, we highlight the challenges associated with medication non-adherence, describe the potential factors that contribute to this public health problem, and explore possible solutions that will help us to move the needle toward greater medication adherence.

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