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Iwashyna TJ, Viglianti EM. Patient and Population-Level Approaches to Persistent Critical Illness and Prolonged Intensive Care Unit Stays. Critical care clinics. 2018 Oct 1; 34(4):493-500.
Abstract: The differential diagnosis of prolonged intensive care unit (ICU) stays includes intrinsic patient and admitting diagnostic characteristics, occurrences during the course of critical illness, and system failures. Existing data suggest that the most common cause of prolonged ICU stay is the development of new cascading problems, which is now more related to ongoing critical illness than the original reason for ICU admission. Accepting the dynamism inherent in such a clinical course has implications for contemporary clinical care.