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Self-reported medication nonadherence predicts cholesterol levels over time.

Blalock DV, Zullig LL, Bosworth HB, Taylor SS, Voils CI. Self-reported medication nonadherence predicts cholesterol levels over time. Journal of psychosomatic research. 2019 Mar 1; 118:49-55.

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OBJECTIVE: Self-report measures of medication nonadherence are frequently adapted to new clinical populations without evidence of validity. We evaluated the predictive validity of a medication nonadherence measure previously validated in patients with hypertension among patients taking cholesterol-reducing medications. METHOD: This secondary analysis involves data from a randomized trial (VA HSRandD IIR 08-297) conducted at the Durham Veterans Affairs Medical Center. At baseline, 6-months, and 12-months, serum cholesterol was obtained and participants (n? = 236) completed a 3-item measure of extent of nonadherence to cholesterol-reducing medications. Two cross-lagged panel models with covariates, in addition to growth curve analysis, were used to examine the predictive utility of self-reported nonadherence on concurrent and future cholesterol levels, while accounting for potential reverse-causation. RESULTS: Extent of nonadherence items produced reliable scores across time and fit a single-factor model (CFI? = 0.99). Nonadherence, and changes in nonadherence, moderately predicted future cholesterol values, and changes in cholesterol values (7 of 9 longitudinal associations were significant at p? < .05; B''s ranged from 0.16 to 0.35). Evidence for reverse associations was weaker (3 of 9 longitudinal associations were significant at p? < .05; B''s ranged from 0.16 to 0.36). CONCLUSION: Analyses support the predictive validity of this medication nonadherence measure over the competing reverse-causation hypothesis.

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