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Duchowny KA, Peters KE, Cummings SR, Orwoll ES, Hoffman AR, Ensrud KE, Cauley JA, Evans WJ, Cawthon PM, Osteoporotic Fractures in Men (MrOS) Study Research Group. Association of change in muscle mass assessed by D -creatine dilution with changes in grip strength and walking speed. Journal of cachexia, sarcopenia and muscle. 2020 Feb 1; 11(1):55-61.
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Abstract: BACKGROUND: Muscle mass declines with age. However, common assessments used to quantify muscle mass are indirect. The D -creatine (D Cr) dilution method is a direct assessment of muscle mass; however, longitudinal changes have not been examined in relation to changes in other measures of muscle mass, strength, and performance. METHODS: A convenience sample of 40 men from the Osteoporotic Fractures in Men Study (mean age = 83.3 years, standard deviation = 3.9) underwent repeat assessment of D Cr muscle mass, dual-energy X-ray absorptiometry (DXA) lean mass, grip strength, and walking speed at two time points approximately 1.6 years apart (2014-2016). One-sample t-tests and Pearson correlations were used to examine changes in DXA total body lean mass, DXA appendicular lean mass/height , DXA appendicular lean mass/weight, D Cr muscle mass, D Cr muscle mass/weight, grip strength, walking speed, and weight. RESULTS: D -creatine muscle mass, D Cr muscle mass/weight, grip strength, and walking speed all significantly declined (all P < 0.01). The change in DXA measures of lean mass was moderately correlated with changes in D Cr muscle mass. There was no significant correlation between the change in DXA measures of lean mass and change in walking speed (all P > 0.05). The change in D Cr muscle mass/weight was moderately correlated with change in walking speed (r = 0.33, P < .05). The change in grip strength was weakly correlated with the change in DXA measures of lean mass and D Cr muscle mass (r = 0.19-0.32). CONCLUSIONS: The results of our study provide new insights regarding the decline in muscle strength and D Cr muscle mass. The D Cr method may be a feasible tool to measure declines in muscle mass over time.

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