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Metabolic parameters in smokers undergoing smoking reduction.

Hsia SH, Nisis ML, Lee ML, Goldstein C, Friedman TC. Metabolic parameters in smokers undergoing smoking reduction. Journal of clinical & translational endocrinology. 2021 Mar 1; 23:100249.

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Abstract:

INTRODUCTION: Few human studies have explored the mechanisms of smoking-induced insulin resistance. : To prospectively examine the metabolic changes of smoking reduction. METHODS: Cigarette smokers (n  =  22; ½-2 packs per day) were enrolled in a smoking reduction program (counseling plus bupropion × 8 weeks; Phase I) followed by monitoring only (no counseling or bupropion × 16 weeks; Phase II). We serially measured exhaled carbon monoxide (CO) and urine nicotine metabolites; fat distribution, and metabolic parameters by hyperinsulinemic clamps including hepatic glucose output (HGO) and indirect calorimetry, adjusted for total caloric intake and expenditure. RESULTS: CO and nicotine metabolite levels fell with smoking reduction during Phase I (all p  <  0.05), without any further changes through Phase II. Central-to-peripheral fat ratio increased during Phase I, but then fell during Phase II (all p  <  0.05). Over 24 weeks, basal HGO fell (p  =  0.02); and falling CO and nicotine metabolite levels correlated inversely with changes in glucose oxidation, and directly with changes in weight (all p  <  0.05). CONCLUSIONS: Smoking reduction produced a transient worsening of central fat redistribution followed by a more significant improvement; along with other net beneficial metabolic effects.




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