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Differences in lymphoma patients between chimeric antigen receptor T-cell therapy trials and the general population.

Apaydin EA, Richardson AS, Baxi S, Vockley J, Akinniranye O, Larkin J, Motala A, Hempel S. Differences in lymphoma patients between chimeric antigen receptor T-cell therapy trials and the general population. Clinical and experimental medicine. 2022 Feb 1; 22(1):151-155.

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Abstract:

Chimeric antigen receptor (CAR)-T cell therapies appear to be promising treatments for non-Hodgkin''s and B-cell lymphoma. However, several CAR-T therapies approved by the US Food and Drug Administration have only been tested for efficacy in relatively few single-arm clinical trials with small sample sizes. We sought to examine the differences between patients in these trials and the general population of patients with non-Hodgkin''s and B-cell lymphoma. Five hundred and twenty-two patients from 15 CAR-T trials found in a systematic review and 417,492 patients from the Surveillance, Epidemiology, and End Results (SEER) Program database were compared. CAR-T study participants appeared to be younger (46.7% under 70 years old vs. 42.2%), more male (68.0% vs. 55.7%), and followed for a shorter period of time compared to patients in the SEER population (mean [M] 45.6 months, 95% confidence interval [CI] 17.7 to 63.3 months follow-up vs. M 57.1 months, 95% CI 57.0 to 57.3 months survival). CAR-T study participants may differ significantly from the general population of patients with non-Hodgkin''s and B-cell lymphoma. Effectiveness of CAR-T therapies in the general population of lymphoma patients may differ from effectiveness demonstrated in trials. Newly created CAR-T patient registries are essential to establishing population-level effectiveness of the therapies.




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