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Palliative clinical trials in advanced chronic liver Disease: challenges and opportunities.
Verma S, Hingwala J, Low JT, Patel AA, Verma M, Bremner S, Haddadin Y, Shinall MC, Komenda P, Ufere NN. Palliative clinical trials in advanced chronic liver Disease: challenges and opportunities. Journal of Hepatology. 2023 Jul 5.
Patients with advanced chronic liver disease have a complex symptom burden and many are not candidates for curative options. Despite this, provision of palliative interventions remains woefully inadequate; lack of an evidence base being a contributory factor. Designing and conducting palliative interventional trials in advanced chronic liver disease remain challenging for a multitude of reasons. In this manuscript we review past and ongoing palliative interventional trials. We identify barriers and facilitators and offer guidance on addressing these challenges. We hope that this will reduce the inequity in palliative care provision in advanced chronic liver disease.