A Randomized Control Trial Testing a Medication Safety Dashboard in Veteran Transplant Recipients.

Taber DJ, Milfred-LaForest S, Rife K, Felkner R, Cooney D, Super N, McClelland S, Buchanan C. A Randomized Control Trial Testing a Medication Safety Dashboard in Veteran Transplant Recipients. Progress in Transplantation (Aliso Viejo, Calif.). 2023 Jun 1; 33(2):121-129.

Related HSR&D Project(s)

• IIR 15-359 – Improving Transplant Medication Safety through a Technology and Pharmacist (ISTEP) Intervention in Veterans

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Abstract:

INTRODUCTION: Medication errors, adverse events, and nonadherence in organ transplant recipients are common and can lead to suboptimal outcomes. A medication safety dashboard was developed to identify issues in medication therapy. RESEARCH QUESTIONS: Can a multicenter bioinformatics dashboard accurately identify clinically relevant medication safety issues in US military Veteran transplant recipients? DESIGN: The dashboard was tested through a 24-month, prospective, cluster-randomized controlled multicenter study. Pharmacists used the dashboard to identify and address potential medication safety issues, which was compared with usual care. RESULTS: Across the 10 sites (5 control sites and 5 intervention sites), 2012 patients were enrolled (1197 intervention vs 831 control). The mean age was 65 (10) years, 95% male, and 27% Black. The dashboard produced 18 132 alerts at a rate of 0.61(0.32) alerts per patient-month, ranging from 0.44 to 0.72 across the 5 intervention sites. Lab-based issues were most common (83.4%), followed by nonadherence (9.4%) and transitions in care (6.4%); 56% of alerts were addressed, taking an average of 43 (29) days. Common responses to alerts included those already resolved by another provider (N? = 4431, 44%), the alert not clinically relevant (N? = 3131, 31%), scheduling of follow-up labs (N? = 591, 6%), and providing medication reconciliation/education (N? = 99, 1%). Inaccurate flags significantly decreased over the study by a mean of -0.6% per month (95% CI -0.1 to -1.0; ? = .0265), starting at 13.4% and ending at 2.6%. CONCLUSION: This multicenter cluster-randomized controlled trial demonstrated that a medication safety dashboard was feasibly deployable across the VA healthcare system, creating valid alerts.