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Dose optimisation and scarce resource allocation: two sides of the same coin.

Strohbehn G, Persad G, Parker WF, Murthy S. Dose optimisation and scarce resource allocation: two sides of the same coin. BMJ open. 2022 Oct 12; 12(10):e063436.

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Abstract:

OBJECTIVE: A deep understanding of the relationship between a scarce drug''s dose and clinical response is necessary to appropriately distribute a supply-constrained drug along these lines. SUMMARY OF KEY DATA: The vast majority of drug development and repurposing during the COVID-19 pandemic - an event that has made clear the ever-present scarcity in healthcare systems -has been ignorant of scarcity and dose optimisation''s ability to help address it. CONCLUSIONS: Future pandemic clinical trials systems should obtain dose optimisation data, as these appear necessary to enable appropriate scarce resource allocation according to societal values.




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