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McDowell TY, Amr S, Langenberg P, Royal W, Bever C, Culpepper WJ, Bradham DD. Time of birth, residential solar radiation and age at onset of multiple sclerosis. Neuroepidemiology. 2011 Jul 28; 34(4):238-44.
These results suggest that exposure early in life to geographical and seasonal factors, possibly related to the protective effect of sunlight, and thus vitamin D, is associated with a delay in MS symptom onset. Other larger studies are required to examine the period-specific (from conception to adulthood) environmental factors that are associated with MS susceptibility.