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Kim HM, Zivin K, Ganoczy D, Pfeiffer P, Hoggatt K, McCarthy JF, Downing K, Valenstein M. Predictors of alternative antidepressant agent initiation among U. S. veterans diagnosed with depression. Pharmacoepidemiology and drug safety. 2010 Oct 1; 19(10):1049-56.
Choice of antidepressant medication for depressed VA patients was associated with important differences in demographic and clinical variables, including psychiatric illness severity, older age, and likelihood of a comorbid anxiety disorder. These findings emphasize the importance of controlling for selection bias when using observational data to compare risks from or effect of mental health treatments.