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Haemodynamic effects of rolofylline in the treatment of patients with heart failure and impaired renal function.

Ponikowski P, Mitrovic V, O'Connor CM, Dittrich H, Cotter G, Massie BM, Givertz MM, Chen E, Murray M, Weatherley BD, Fujita KP, Metra M. Haemodynamic effects of rolofylline in the treatment of patients with heart failure and impaired renal function. European journal of heart failure : journal of the Working Group on Heart Failure of the European Society of Cardiology. 2010 Nov 1; 12(11):1238-46.

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Abstract:

Single administration of rolofylline in patients with HF and impaired renal function produced a slight decrease in mean PAP and consistently increased diuresis and natriuresis without compromising renal function, both before and after administration of i.v. loop diuretics.




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