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Magid DJ, Shetterly SM, Margolis KL, Tavel HM, O'Connor PJ, Selby JV, Ho PM. Comparative effectiveness of angiotensin-converting enzyme inhibitors versus beta-blockers as second-line therapy for hypertension. Circulation. Cardiovascular quality and outcomes. 2010 Sep 1; 3(5):453-8.
ACE inhibitors and ß-blockers are equally effective in lowering BP and preventing cardiovascular events for patients whose BP is not controlled with a thiazide diuretic alone and who have no compelling indication for a specific 2nd-line agent.