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Mandava P, Sarma A, Anderson JA, Wehner B, Kent T. Gender and race interact to influence outcome of ischemic stroke after treatment with rt-PA. [Abstract]. Stroke; A Journal of Cerebral Circulation. 2011 Mar 1; 42(3):e164.
There is considerable interest in identifying differential subgroup effects of rt-PA, however often with discrepant results, especially regarding gender. Group imbalances in factors associated with outcome may contribute to discrepancies. Conventional statistical means by which imbalances are usually adjusted are based on assumptions of relationships between these factors that may not be valid. Subgroup analyses are especially vulnerable to imbalances as their numbers dwindle or issues such as recruitment bias emerge. We have developed new methods that accommodate imbalances and applied them to assess the influence of gender and race on rt-PA outcomes.
