Talk to the Veterans Crisis Line now
U.S. flag
An official website of the United States government

Health Services Research & Development

Go to the ORD website
Go to the QUERI website

HSR&D Citation Abstract

Search | Search by Center | Search by Source | Keywords in Title

PPI use in the OTC era: who to treat, with what, and for how long?

Inadomi JM, Fendrick AM. PPI use in the OTC era: who to treat, with what, and for how long? Clinical Gastroenterology and Hepatology. 2005 Mar 1; 3(3):208-15.

Dimensions for VA is a web-based tool available to VA staff that enables detailed searches of published research and research projects.

If you have VA-Intranet access, click here for more information vaww.hsrd.research.va.gov/dimensions/

VA staff not currently on the VA network can access Dimensions by registering for an account using their VA email address.
   Search Dimensions for VA for this citation
* Don't have VA-internal network access or a VA email address? Try searching the free-to-the-public version of Dimensions



Abstract:

Proton pump inhibitors (PPIs) have been shown to be the most effective class of medication to treat gastroesophageal reflux disease (GERD). The availability of over-the-counter (OTC) and generic PPIs provides consumers with options other than antacids and histamine 2 -receptor antagonists (H2RAs) for self-medication of heartburn and acid regurgitation. Medical concerns arising from these developments include management of patients in whom symptoms persist despite OTC PPI, proper administration of PPIs, and potential masking of more serious pathology, such as malignancy. Current studies indicate that it is likely that different forms of PPI administration will become more acceptable, such as on-demand and intermittent therapy. Prospective clinical trials show the efficacy of these strategies of noncontinuous PPI administration, and the potential for cost reduction in GERD management. Newer agents such as reversible acid pump antagonists will compete for selected markets in the future, further expanding the role of alternative dosing regimens. Ultimately, therapy should be tailored to individual patients because no single strategy will be optimal for the entire population with GERD symptoms.





Questions about the HSR&D website? Email the Web Team.

Any health information on this website is strictly for informational purposes and is not intended as medical advice. It should not be used to diagnose or treat any condition.