Excess mortality in bipolar disorders.

Miller C, Bauer MS. Excess mortality in bipolar disorders. Current psychiatry reports. 2014 Nov 1; 16(11):499.

Related HSR&D Project(s)

• IIR 10-314 – Spatiotemporal Spread of Newer Antipsychotics for Bipolar Disorder and PTSD

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Abstract:

Bipolar disorder is associated with high mortality, and people with this disorder on average may die 10-20 years earlier than the general population. This excess and premature mortality continues to occur despite a large and expanding selection of treatment options dating back to lithium and now including anticonvulsants, antipsychotics, and evidence-based psychotherapies. This review summarizes recent findings on mortality in bipolar disorder, with an emphasis on the role of suicide (accounting for about 15% of deaths in this population) and cardiovascular disease (accounting for about 35-40% of deaths). Recent care models and treatments incorporating active outreach, integrated mental and physical health care, and an emphasis on patient self-management have shown promise in reducing excess mortality in this population.