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Stroke Risk Stratification in Atrial Fibrillation: Bridging the Evidence Gaps.

Turakhia MP, Estes NA. Stroke Risk Stratification in Atrial Fibrillation: Bridging the Evidence Gaps. Journal of Cardiovascular Electrophysiology. 2016 Mar 1; 27(3):271-3.

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Abstract:

One of the fundamental principles of evidence based medicine is that clinical practice should be based on a sound scientific foundation of data established in clinical studies involving human subjects. The level of evidence needed for adoption of these therapies should vary according to the clinical situation; the higher the stakes, the better the evidence should be. The stakes grow higher in proportion to the size of the affected population, severity of the illness, and risks and cost of the therapy. One-fourth of the 700,000 strokes occurring annually in the United States result from embolization of thrombus from the left atrial appendage in patients with atrial fibrillation (AF). Currently cerebrovascular accidents represent the major cause of disability and the third leading cause of death in the US. In addition, the prevalence of AF is expected to increase threefold over the next three decades. Based on these considerations, it is evident that the stakes are high for clinical strategies for risk stratification and stroke prevention in AF patients.(1,2) This article is protected by copyright. All rights reserved.




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