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Systemic and localized extra-central nervous system bacterial infections and the risk of dementia among US veterans: A retrospective cohort study.

Mawanda F, Wallace RB, McCoy K, Abrams TE. Systemic and localized extra-central nervous system bacterial infections and the risk of dementia among US veterans: A retrospective cohort study. Alzheimer's & dementia : diagnosis, assessment & disease monitoring. 2016 Sep 10; 4:109-117.

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Abstract:

INTRODUCTION: Emerging evidence indicates associations between extra-central nervous system (CNS) bacterial infections and an increased risk for dementia; however, epidemiological evidence is still very limited. METHODS: This study involved a retrospective cohort of a national sample of US veterans (N  =  417,172) aged = 56 years. Extended Cox proportional hazard models adjusted for demographic characteristics and medical and psychiatric comorbidities determined the associations between systemic and localized extra-CNS bacterial infections occurring > 2 years before the initial dementia diagnosis and the risk for dementia. RESULTS: Exposure to any extra-CNS bacterial infection was associated with a significantly increased risk for dementia (hazard ratio [HR]  =  1.20 [95% confidence interval  =  1.16-1.24]). Independently, septicemia (HR  =  1.39 [1.16-1.66]), bacteremia (HR  =  1.22 [1.00-1.49]), osteomyelitis (HR  =  1.20 [1.06-1.37]), pneumonia (HR  =  1.10 [1.02-1.19]), urinary tract infections (HR  =  1.13 [1.08-1.18]), and cellulitis (HR  =  1.14 [1.09-1.20]) were associated with a significantly increased risk for dementia. DISCUSSION: Both systemic and localized extra-CNS bacterial infections are associated with an increased risk for developing dementia.





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