Talk to the Veterans Crisis Line now
U.S. flag
An official website of the United States government

Health Services Research & Development

Go to the ORD website
Go to the QUERI website

Mild TBI Diagnosis and Management Strategies

Prazosin for Mild Traumatic Brain Injury Comorbidities: Toward a Precision Medicine Approach


by Murray Raskind, MD
Seminar date: 1/4/2018

Description: Prazosin, a brain penetrant alpha 1 adrenoreceptor antagonist, has been demonstrated effective for combat trauma PTSD in active duty soldiers who experienced mTBIs in Iraq and/or Afghanistan. Higher pretreatment blood pressure is a biomarker that predicts greater PTSD symptom reduction during prazosin treatment. Persistent postconcussive headaches and alcohol use disorder are additional mTBI comorbidities responsive to prazosin and other brain penetrant alpha 1 AR antagonists. Intended audience: provider prescribers, pharmacists, other healthcare professionals caring for Veterans, and Veterans themselves.



DOWNLOAD: PDF handout | Audio only (mp3) | transcript


Questions about the HSR&D website? Email the Web Team.

Any health information on this website is strictly for informational purposes and is not intended as medical advice. It should not be used to diagnose or treat any condition.