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Mild TBI Diagnosis and Management Strategies
Spotlight on Evidence Synthesis Program

Systematic Review: Relationship of mTBI to PTSD, Depression, Substance Abuse, Suicidal Ideation, and Anxiety Disorders


by David Cifu, MD ; Ralph DePalma, MD, FACS ; Nancy Greer, PhD ; Stuart Hoffman, PhD
Seminar date: 11/8/2018

Description: This systematic review will answer the following: 1a: Is the prevalence of psychiatric conditions (posttraumatic stress disorder [PTSD], depressive disorders, substance use disorders, suicidal ideation or attempts, and anxiety disorders) different in service members and Veterans with and without deployment-related mild traumatic brain injury (mTBI) (one or more)? 1b: How do severity and persistence of psychiatric conditions (PTSD, depressive disorders, substance use disorders, suicidal ideation or attempts, and anxiety disorders) differ in service members and Veterans with and without deployment-related mTBI? 2. What are the effectiveness and comparative effectiveness and harms of interventions for treatment of PTSD, depressive disorders, substance use disorders, suicidal ideation or attempts, and anxiety disorders in service members and Veterans with history of deployment-related mTBI? Drs. Stuart Hoffman, David Cifu, and Ralph Depalma will provide commentary and take questions at the end of the session. Intended audience: Researchers, clinicians, and all others interested in the relationship of mTBI to various mental health conditions. ACKNOWLEDGMENTS: This topic was developed in response to a nomination by Stuart Hoffman, PhD, Scientific Program Manager for Brain Injury and Senior Scientific Advisor for Brain Injury; Ralph DePalma, MD, FACS, Special Operations Officer; and David X. Cifu, MD, National Director of Physical Medicine and Rehabilitation Program Office and Chair, VHA TBI Advisory Committee, for use by the VHA TBI Advisory Committee to inform clinical practice guideline development and by the Office of Research and Development to inform future research priorities. The scope was further developed with input from the topic nominators (ie, Operational Partners), the ESP Coordinating Center, the review team, and the technical expert panel (TEP).



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