Talk to the Veterans Crisis Line now
U.S. flag
An official website of the United States government

VA Health Systems Research

Go to the VA ORD website
Go to the QUERI website

Ralph G. DePalma Memorial TBI Clinical Strategies

Poor Sleep Correlates with Biomarkers of Neurodegeneration in Mild Traumatic Brain Injury Patients: a LIMBIC-CENC Study

by Kimbra Kenney, MD ; Kent Werner, MD, PhD
Seminar date: 5/4/2021

Description: Traumatic brain injury (TBI) and sleep disorders are each independently associated with neurodegeneration, but longitudinal TBI studies measuring the incidence of dementia have not considered potential neurodegenerative effects of co-morbid sleep dysfunction. We collected sleep quality scores, plasma biomarkers of neurodegeneration and cognitive scores in 182 CENC longitudinal study participants enrolled 2–15 years after TBI and found that sleep quality correlates with plasma levels of neurofilament light and tau as well as two independent measures of cognitive ability, suggesting a novel, treatable pathomechanism of TBI-associated cognitive dysfunction/dementia.

Intended audience:Healthcare providers who care for patients with remote mTBI with co-morbid sleep dysfunction, and neuroscientists studying remote effects of TBI and sleep on cognition.

View archived session video:

DOWNLOAD: PDF handout | Audio only (mp3) | transcript

Questions about the HSR website? Email the Web Team

Any health information on this website is strictly for informational purposes and is not intended as medical advice. It should not be used to diagnose or treat any condition.