Pharmacotherapy for the Treatment of Cannabis Use Disorder: A Systematic Review

Prepared by: Evidence Synthesis Program (ESP) Center Portland VA Medical Center Portland, OR Devan Kansagara, MD, MCR, Director Recommended citation: Kondo K, Morasco BJ, Nugent S, Ayers C, O'Neil ME, Freeman M, Paynter R, and Kansagara D. Pharmacotherapy for the treatment of cannabis use disorder: a systematic review.

Download PDF: Complete Report, Executive Summary, Report, Appendices

Aim

We conducted a systematic review and meta-analysis of the benefits and risks associated with the use of various pharmacotherapies for the achievement of abstinence, the promotion of cessation or reduction of cannabis use, and retention among individuals with cannabis use disorder (CUD).

Key Questions

KQ1: What are the benefits and harms of pharmacotherapy for cannabis use disorder?

KQ2: Are there known subpopulations for whom currently used pharmacotherapy is most/least effective for cannabis use disorder?

See also

Pharmacotherapy for the Treatment of Cannabis Use Disorder: A Systematic Review (Management eBrief)

Cannabis Provider Education Packet

Kondo K, Morasco B, Nugent S, et al. Pharmacotherapy for the Treatment of Cannabis Use Disorder: A Systematic Review. Annals of Internal Medicine. Published online March 3, 2020. DOI: 10.7326/M19-1105.

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