Hepatitis C is a liver infection caused by the hepatitis C virus. Hepatitis C can range from a mild illness lasting a few weeks to a serious, lifelong illness. Hepatitis C is often described as “acute,” meaning a new infection or “chronic,” meaning lifelong infection. The virus is most commonly spread through sharing needles syringes, or other equipment used to inject drugs; accidental needle-sticks in healthcare settings; and being born to a mother who is already infected. VA research into hepatitis C addresses prevention, treatment, and managing quality of life.
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(5 of more than 435 HEPATITIS C focused publications)
- Lymberopoulos P, Shaikh A, Rich NE, Benhammou JN, Kanwal F, Cholankeril G, Liver Cancer Investigator Working Group , Lee TH, Goss J, Rana A, Kim D, Ahmed A. Comparable survival for hepatitis C-related hepatocellular carcinoma after liver transplantation irrespective of viremic status. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 2022 Mar 25.
- Mueller PP, Chen Q, Ayer T, Nemutlu GS, Hajjar A, Bethea ED, Peters MLB, Lee BP, Janjua NZ, Kanwal F, Chhatwal J. Duration and cost-effectiveness of hepatocellular carcinoma surveillance in hepatitis C patients after viral eradication. Journal of Hepatology. 2022 Feb 12.
- Kramer JR, Puenpatom A, Cao Y, Yu X, El-Serag HB, Kanwal F. Treatment of hepatitis C virus infection in people with opioid use disorder: a real-world study of elbasvir/grazoprevir in a US Department of Veterans Affairs population. The American journal of drug and alcohol abuse. 2022 Jan 25; 1-9.
- Yakovchenko V, Morgan TR, Chinman MJ, Powell BJ, Gonzalez R, Park A, Malone PS, Chartier M, Ross D, Rogal SS. Mapping the road to elimination: a 5-year evaluation of implementation strategies associated with hepatitis C treatment in the veterans health administration. BMC health services research. 2021 Dec 18; 21(1):1348.
- D'Ambrosio R, Ioannou GN. Hepatocellular Carcinoma Risk, Outcomes, and Screening After Hepatitis C Eradication. Hepatology communications. 2021 Sep 1; 5(9):1465-1468.
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(5 of more than 19 HEPATITIS C focused publication briefs)
- High Virologic Cure Rates for Hepatitis C Virus among Veterans with Opioid Use Disorder Treated with Elbasvir/Grazoprevir
Elbasvir (EBR)/grazoprevir (GZR) is a fixed-dose combination treatment for hepatitis C virus (HCV). This study sought to evaluate the real-world effectiveness of EBR/GZR among Veterans with HCV genotype (GT) 1 who also had a diagnosis of opioid use disorder (OUD). Findings showed that high rates of virologic cure were achieved among VA patients with HCV, OUD, and multiple comorbidities, including ...
Date: January 25, 2022
- Veterans Advocate Treating “Sickest First” When Discussing Limited Resources for Hepatitis C Treatment
Investigators in this study used Democratic Deliberation (DD) methods as a proof of concept for informing policy decisions related to the allocation of scarce resources for treatment of chronic hepatitis C virus in VA. Findings showed that most Veterans endorsed a sickest-first policy over a first-come-first-served policy, emphasizing the ethical and medical appropriateness of treating the sickest...
Date: May 1, 2020
- VA Successfully Implements Interferon-free Treatment for Hepatitis C Virus in Previously Undertreated Patient Populations
This study examined the adoption of interferon-free treatment for hepatitis C virus (HCV) in VA to learn who received this therapy and whether the limitations of interferon-containing treatments have been overcome, including low rates of use among VA healthcare users who are African American or Hispanic, and among those with HCV-HIV co-infection. Findings showed that with the advent of interferon-...
Date: March 7, 2018
- HCV-Related Complications Increasing among Women Veterans
This study examined gender-related differences in the incidence and prevalence of cirrhosis, decompensated cirrhosis, and hepatocellular cancer (HCC) between 2000 and 2013. Findings showed that the incidence and prevalence of hepatitis C virus (HCV) complications was higher in men than in women. However, the rate of increase in the incidence rates of cirrhosis and decompensated cirrhosis among HCV...
Date: November 1, 2017
- Direct-Acting Antiviral Agents Reduce Risk of Hepatocellular Cancer among Veterans with Hepatitis C
This study examined the risk of hepatocellular cancer (HCC) following sustained virological response (SVR) among 22,500 Veterans with hepatitis C virus (HCV) who received directing-acting antivirals (DAA) treatment at any of 129 VA hospitals between January and December 2015. Findings showed that in Veterans treated with DAAs, SVR was associated with a 76% reduction in the risk of developing hepat...
Date: October 1, 2017
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( 5 of more than 27 HEPATITIS C focused projects
|| Advanced Prediction Models to Optimize Treatment and Access for Veterans with Hepatitis C
|| Quality of Care for Hepatitis C in Veterans Who Are Homeless
|| Care for Women Veterans with Hepatitis C Virus Infection
|| Web-based Intervention to Reduce Alcohol Use in Veterans with Hepatitis C
|| Cost-effective Uses of New Hepatitis C Treatments and their VA Budgetary Impact
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HSR&D Briefs, Reports, Newsletters
5 sample "Hepatitis C" publications displayed.
Management Briefs eBrief-no67 -- Assessment of Alternative Treatment Strategies for Chronic Genotype 1 Hepatitis C
Strategies for Chronic Genotype 1 Hepatitis C...Genotype 1 Hepatitis C: A Systematic Review Chronic genotype 1 (GT1) Hepatitis C (HCV)...Strategies for Chronic Genotype 1 Hepatitis C. VA ESP Project #05-226, 2012. View
Evidence Synthesis Program Reports
Strategies for Chronic Genotype 1 Hepatitis C 2013-03 Evidence Brief: Developing
Evidence Brief: Staffing Models in Specialty Care - Supplemental Materials
............................ 5 Appendix C: Evidence Tables ......................Gastroenterology/ OR HIV/ OR Hepatitis B/ OR Hepatitis C/ OR Infectious Disease Medicine/
FORUM, Spring 2017: Implementation Science
Increase Hepatitis C Treatment Starts Rachel Gonzalez, MPH, National Hepatitis C Resource...System, Pittsburgh, Pennsylvania Hepatitis C virus (HCV) infection is a leading
FORUM, Spring 2017: Implementation Science
...record data... Strategies to Increase Hepatitis C Treatment Starts By Rachel Gonzalez...Gonzalez, MPH, National Hepatitis C Resource Center, VA Long Beach Healthcare System
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