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IIR 16-210 – HSR Study

IIR 16-210
Addressing inappropriate benzodiazepine prescribing among older Veterans
Donovan Maust, MD MS
VA Ann Arbor Healthcare System, Ann Arbor, MI
Ann Arbor, MI
Funding Period: February 2018 - January 2022
Benzodiazepine (BZD) use is a significant and persistent concern among older Veterans given the association of BZDs with adverse outcomes including falls, fractures, motor vehicle accidents, impaired cognition, increased risk of dementia, and mortality. In FY2015, over 82,000 Veterans 75 years of age were prescribed a BZD despite abundant evidence of harms from both acute and chronic use and recommendations from professional organizations to limit use. Beginning in FY2013, the VA's Psychotropic Drug Safety Initiative (PDSI) began monitoring a variety of psychotropic quality measures, including BZD use among Veterans 75 years of age (hereafter referred to as "BZD 75"). Among the 52 facilities (out of 140) that selected BZD 75 as a priority, each developed its own local strategy to improve prescribing. In order for the VA to build upon local successes at addressing the seemingly intractable problem of BZD prescribing, the aim of this proposal is to understand the combinations of local facility strategies and context that generate these outcomes. In addition, it is critical to understand the patient experience of these strategies, as Veterans may experience some "successful" strategies as extremely distressful.
This work may directly influence the clinical care of Veterans and is of both great interest and immediate relevance to our operational partners, including PDSI, Pharmacy Benefits Management, and the Academic Detailing Service.

Aim 1: Identify high- and low-performing facilities on acute and chronic BZD prescribing among facilities that prioritized the BZD 75 measure. Aim 2: Assess facility-level strategies and associated barriers and facilitators to addressing the BZD 75 goal along with the acceptability of those strategies to older Veterans. Aim 3: Identify and pilot test context-sensitive strategies for facilities to successfully reduce both acute and chronic BZD use among older Veterans.

We will use interrupted time-series analyses of national VA administrative data to examine BZD prescribing across BZD 75 priority facilities (n=52). We will specifically measure change in: (1) rate of acute use (new BZD initiation) and (2) intensity of chronic use (average daily dose [mg/day]). As an exploratory sub-aim, we will measure the rate of fall-related injury by facility to determine whether change in BZD prescribing is associated with change in associated adverse outcomes. In Aim 2a we will conduct semi-structured telephone interviews with up to 16 PDSI local facility champions and additional staff from top- and bottom-performing facilities (identified in Aim 1), followed by on-site, semi-structured interviews with key stakeholders at up to 6 sites. We will gather information on facility-level strategies, barriers, and facilitators that may help or hinder facility efforts. Finally, we will conduct telephone interviews with older Veterans prescribed chronic BZDs that attempted a taper to learn whether patients experienced these facility strategies as distressful. An expert panel of clinicians, researchers, and administrators will review the strategies, local context, associated BZD prescribing outcomes, and patient acceptability to develop a toolkit of context-sensitive best practices facilities can implement to address BZD use, which we will then pilot test.

none at this time

BZD use continues among older adults, despite decades of evidence of associated harms; intervention studies have done little to help address this problem in routine clinical care. At the end of our study, we will have developed a toolkit of context-sensitive best practices acceptable to older Veterans that can help inform facility initiates to reduce acute and chronic BZD prescribing and may also benefit other VA safe-prescribing initiatives.

External Links for this Project

NIH Reporter

Grant Number: I01HX002340-01A1

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Journal Articles

  1. Lei L, Strominger J, Wiechers IR, Kim HM, Blow FC, Bohnert ASB, Min L, Krein SL, Maust DT. Benzodiazepine Prescribing from VA and Medicare to Dually Enrolled Older Veterans: A Retrospective Cohort Study. Journal of general internal medicine. 2021 Dec 1; 36(12):3689-3696. [view]
  2. Maust DT, Kim HM, Wiechers IR, Ignacio RV, Bohnert ASB, Blow FC. Benzodiazepine Use among Medicare, Commercially Insured, and Veteran Older Adults, 2013-2017. Journal of the American Geriatrics Society. 2021 Jan 1; 69(1):98-105. [view]
  3. Timko C, Hoggatt KJ, Esmaeili A, Lewis E, Lor MC, Maust DT, Nevedal AL. Long-Term Benzodiazepine Use and Discontinuation Among Patients in the U.S. Veterans Health Administration. Psychiatric services (Washington, D.C.). 2022 Nov 1; 73(11):1217-1224. [view]
  4. Kim HM, Strominger J, Zivin K, Van T, Maust DT. Relationship between facility number of clinicians and prescribing intensity of psychotropic medications, opioids, and antibiotics in ambulatory practice. BMC health services research. 2024 Feb 16; 24(1):217. [view]
  5. Maust DT, Takamine L, Wiechers IR, Blow FC, Bohnert ASB, Strominger J, Min L, Krein SL. Strategies Associated With Reducing Benzodiazepine Prescribing to Older Adults: A Mixed Methods Study. Annals of Family Medicine. 2022 Jul 1; 20(4):328-335. [view]

DRA: Aging, Older Veterans' Health and Care
DRE: TRL - Applied/Translational
Keywords: Medication Management
MeSH Terms: none

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