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IIR 20-280 – HSR Study

IIR 20-280
Leveraging inpatient antimicrobial stewardship infrastructure to improve antimicrobial-prescribing at hospital discharge
Daniel J Livorsi, MD MS
Iowa City VA Health Care System, Iowa City, IA
Iowa City, IA
Funding Period: July 2022 - June 2026


Background: Antimicrobial overuse is one of the strongest risk factors for the emergence of antimicrobial resistance, an urgent public health problem. Antimicrobial stewardship programs (ASPs) are hospital-based programs that can reduce unnecessary inpatient antimicrobial use and are therefore an essential tool for addressing the crisis of antimicrobial resistance. ASPs are mandated in VHA. Significance: VHA hospitals are only required to monitor their inpatient antimicrobial use. However, at least 40% of antimicrobial exposure associated with a VHA hospital stay is prescribed at hospital discharge and is taken by the patient after discharge (i.e. post-discharge). These post-discharge antimicrobial prescriptions are frequently unnecessary or sub-optimal. Reducing post-discharge antimicrobial overuse will minimize patient harm, such as Clostridioides difficile infections, antimicrobial resistance, and adverse drug events. Innovation and Impact: This proposal will address two critical gaps in the literature. First, standard ASP metrics do not capture post-discharge antimicrobial use and therefore miss a substantial amount of hospital- related antimicrobial exposure. This proposal will evaluate factors that contribute to variation in post-discharge antimicrobial use across patients and hospitals in order to inform both metric development and the design of future stewardship interventions. Second, while there are evidence-based strategies for safely reducing inpatient antimicrobial use, it is unclear how current inpatient ASP activities can decrease post-discharge antimicrobial overuse. This proposal will explore how inpatient ASP infrastructure, which all VHA hospitals are expected to have, can be leveraged to reduce unnecessary post-discharge antimicrobial-prescribing. Specific Aims: Aim 1: Identify factors that contribute to variation in post-discharge antimicrobial use in VHA acute-care admissions across all facilities by evaluating potential patient-level, hospital-level, and environmental effects. Identify hospitals that have low observed-to-expected post-discharge antimicrobial use, low risk-adjusted inpatient antimicrobial use, and perform well on clinical outcomes in antimicrobial-treated patients. Aim 2: Determine whether being admitted to a hospital with a discharge-focused stewardship process is associated with less post-discharge antimicrobial exposure, after adjusting for differences in case-mix, ID expertise, inpatient antimicrobial exposure, and the intensity of inpatient ASP activities. Aim 3: Using qualitative methods, evaluate attitudes and processes that impede or foster reductions in unnecessary post-discharge antimicrobial use. We will perform site visits at 6 high- and 4 low-performing sites, as identified in Aim 1. Methodology: Aim 1 will use VINCI data and linear mixed models to identify factors that influence post- discharge antimicrobial use. Aim 1 will also rank hospitals on their performance on inpatient and post- discharge antimicrobial use plus associated clinical outcomes. In Aim 2, we will leverage VINCI data and findings from a mandatory hospital-level stewardship survey conducted in VHA during November 2020. We will evaluate the effect of a discharge-specific stewardship process on post-discharge antimicrobial use. In Aim 3, we will conduct semi-structured interviews with key stakeholders at 10 hospitals to explore determinants of post-discharge antimicrobial overuse and perceptions of the post-discharge antimicrobial use metric that we developed in Aim 1. Our approach will be based in the i-PARIHS framework. Next Steps/Implementation: The standardized hospital-level metrics we develop in Aim 1 could be incorporated into an interactive ASP dashboard our Patient Safety Center of Inquiry has already built and is pilot-testing in VISN 23. Our findings from Aims 2 and 3 could be incorporated into future stewardship surveys within VHA while informing the processes local ASPs choose to implement to reduce post-discharge antimicrobial overuse. Our findings could serve as the basis for a multicenter, audit-and-feedback trial focused on stewardship at hospital discharge and future work around re-designing ASP processes at discharge.

External Links for this Project

NIH Reporter

Grant Number: I01HX003325-01A2

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Journal Articles

  1. Livorsi DJ, Merchant JA, Cho H, Goetz MB, Alexander B, Beck B, Goto M. A novel risk-adjusted metric to compare hospitals on their antibiotic-prescribing at hospital discharge. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2024 Apr 24. [view]
  2. Heren JE, Lund BC, Alexander B, Livorsi DJ. Procalcitonin Monitoring and Antibiotic Duration in Presumed Lower Respiratory Tract Infections: A Propensity Score-Matched Cohort Across the Veterans Health Administration. Open forum infectious diseases. 2023 Nov 1; 10(11):ofad520. [view]

DRA: Health Systems
DRE: TRL - Applied/Translational
Keywords: Adverse Event Monitoring, Best Practices, Organizational Structure
MeSH Terms: None at this time.

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