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HIS 99-039 – HSR Study

HIS 99-039
Improving the HIV/AIDS Immunology Case Registry
Samuel A. Bozzette, MD PhD
VA San Diego Healthcare System, San Diego, CA
San Diego, CA
Barbara Phillips PhD
VA San Diego Healthcare System, San Diego, CA
San Diego, CA
Funding Period: October 1999 - September 2002
This project is to continue to develop the basic QUERI effort to translate findings regarding appropriate regimens of care in light of inappropriate variation of actual practice. The means to support this effort is to develop the Immunology Case Registry (ICR) into a research database called the HIV Quality Enhancement Database (QED).

The group that has been working on the QUERI project will now extend their translation effort by integrating the SDR into a translation SDP, refocusing the SDR objective and building on their previous QUERI work.

This project utilizes an existing VA HIV registry to develop a research database to support quality improvement efforts in the area of HIV/AIDS care in the VA setting. Methods included data cleaning and standardization, evaluating completeness of data, performing internal logic checks and accuracy, augmenting ICR data using external sources, imputing missing values, and deriving a set of variables for other research.

In the course of developing the QED, we have identified a number of deficiencies in building the QED solely on ICR data. The deficiencies include incomplete case ascertainment, incomplete laboratory data, and a lack of data standardization. The staff is now taking steps to address these deficiencies through validation and augmentation with external data sources.

Discovery of HIV-infected patients not included in the ICR. Clearer understanding of the influence of ARVs on the risk of cardiovascular diseases. QED data have been used by other researchers in the area of adherence to ARV medications and guidelines of care, and screening.

External Links for this Project

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None at this time.

DRA: Health Systems
DRE: Technology Development and Assessment, Epidemiology
Keywords: HIV/AIDS, Research method
MeSH Terms: Observational Study, HIV

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