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CDA 10-019 – HSR&D Study

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CDA 10-019
Improving Glaucoma Medication Adherence
Kelly W. Muir MD MHSc
Durham VA Medical Center, Durham, NC
Durham, NC
Funding Period: January 2011 - December 2015

BACKGROUND/RATIONALE:
Glaucoma is the leading cause of irreversible blindness worldwide and disproportionately affects the elderly and African-Americans in both prevalence and severity. The number of Americans with glaucoma is expected to increase by 50% in the next 15 years. Multiple studies have shown that with effective medical treatment, much glaucomatous vision loss can be prevented through reduction in intraocular pressure. Despite this, glaucoma medications often are not taken as prescribed.

OBJECTIVE(S):
The overall objective of the projects included in this career development award is to reduce vision loss in veterans with glaucoma by identifying and reducing barriers to glaucoma medication adherence.

METHODS:
The first study of this program is an observational study comparing different methods for quantifying glaucoma medication adherence: electronic monitors, self-report, pharmacy refill records, and direct observation of drop instillation technique. These methods of measuring adherence will be compared to each other and to clinically relevant outcomes including intraocular pressure and visual field deterioration. The second study involves the qualitative assessment and refinement of a prototype intervention to improve medication adherence. Finally, the refined intervention will be pilot tested in patients with glaucoma.

FINDINGS/RESULTS:
Not yet available.

IMPACT:
The successful completion of these projects led to the study design proposed for a randomized controlled trial described in a recent IIR application. If successful, the intervention proposed will lead to less preventable vision loss in veterans. Blindness from glaucoma leads to worse quality of life and loss of independence. By reducing glaucoma-related blindness we hope to maintain quality of life and independent living for veterans affected by glaucoma.

PUBLICATIONS:

Journal Articles

  1. Williams AM, Muir KW. Awareness and attitudes toward corneal donation: challenges and opportunities. Clinical ophthalmology (Auckland, N.Z.). 2018 Jun 7; 12:1049-1059.
  2. Thompson AC, Woolson S, Olsen MK, Danus S, Bosworth HB, Muir KW. Relationship between electronically measured medication adherence and vision-related quality of life in a cohort of patients with open-angle glaucoma. BMJ open ophthalmology. 2018 Feb 19; 3(1):e000114.
  3. Thompson AC, Manjunath V, Muir KW. Risk Factors for Earlier Reexposure of Glaucoma Drainage Devices. Journal of glaucoma. 2017 Dec 1; 26(12):1155-1160.
  4. Whigham B, Oddone EZ, Woolson S, Coffman C, Allingham RR, Shieh C, Muir KW. The influence of oral statin medications on progression of glaucomatous visual field loss: A propensity score analysis. Ophthalmic Epidemiology. 2018 Jun 1; 25(3):207-214.
  5. Davies I, Williams AM, Muir KW. Aids for eye drop administration. Survey of ophthalmology. 2017 May 1; 62(3):332-345.
  6. Carpenter DM, Blalock SJ, Sayner R, Muir KW, Robin AL, Hartnett ME, Giangiacomo AL, Tudor GE, Sleath BL. Communication Predicts Medication Self-Efficacy in Glaucoma Patients. Optometry and vision science : official publication of the American Academy of Optometry. 2016 Jul 1; 93(7):731-7.
  7. Kumar JB, Bosworth HB, Sleath B, Woolson S, Olsen M, Danus S, Muir KW. Quantifying Glaucoma Medication Adherence: The Relationship Between Self-Report, Electronic Monitoring, and Pharmacy Refill. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. 2016 Jul 1; 32(6):346-54.
  8. Williams AM, Allingham RR, Stamer WD, Muir KW. Eye Care Professionals' Perspectives on Eye Donation and an Eye Donation Registry for Research: A Single-Institution, Cross-Sectional Study. Current eye research. 2016 Jun 1; 41(6):867-71.
  9. Sayner R, Carpenter DM, Robin AL, Blalock SJ, Muir KW, Vitko M, Hartnett ME, Lawrence SD, Giangiacomo AL, Tudor G, Goldsmith JA, Sleath B. How glaucoma patient characteristics, self-efficacy and patient-provider communication are associated with eye drop technique. The International journal of pharmacy practice. 2016 Apr 1; 24(2):78-85.
  10. Carpenter DM, Sayner R, Blalock SJ, Muir KW, Hartnett ME, Lawrence SD, Giangiacomo AL, Goldsmith JA, Tudor GE, Robin AL, Sleath BL. The Effect of Eye Drop Technique Education in Patients With Glaucoma. Health communication. 2016 Aug 1; 31(8):1036-42.
  11. Vin A, Schneider S, Muir KW, Rosdahl JA. Health coaching for glaucoma care: a pilot study using mixed methods. Clinical ophthalmology (Auckland, N.Z.). 2015 Oct 22; 9:1931-43.
  12. Sleath B, Carpenter DM, Blalock SJ, Sayner R, Muir KW, Slota C, Giangiacomo AL, Hartnett ME, Tudor G, Robin AL. Applying the resources and supports in self-management framework to examine ophthalmologist-patient communication and glaucoma medication adherence. Health Education Research. 2015 Oct 1; 30(5):693-705.
  13. Rosdahl JA, Muir KW. Finding the best glaucoma questionnaire: a qualitative and quantitative evaluation of glaucoma knowledge assessments. Clinical ophthalmology (Auckland, N.Z.). 2015 Sep 29; 9:1845-52.
  14. Sayner R, Carpenter DM, Blalock SJ, Robin AL, Muir KW, Hartnett ME, Giangiacomo AL, Tudor G, Sleath B. Accuracy of Patient-reported Adherence to Glaucoma Medications on a Visual Analog Scale Compared With Electronic Monitors. Clinical therapeutics. 2015 Sep 1; 37(9):1975-85.
  15. Stone JS, Muir KW, Stinnett SS, Rosdahl JA. Glaucoma Blindness at a Tertiary Eye Care Center. North Carolina Medical Journal. 2015 Sep 1; 76(4):211-8.
  16. Carpenter DM, Tudor GE, Sayner R, Muir KW, Robin AL, Blalock SJ, Hartnett ME, Giangiacomo AL, Sleath BL. Exploring the influence of patient-provider communication on intraocular pressure in glaucoma patients. Patient education and counseling. 2015 Jul 6.
  17. Slota C, Sayner R, Vitko M, Carpenter DM, Blalock SJ, Robin AL, Muir KW, Hartnett ME, Sleath B. Glaucoma patient expression of medication problems and nonadherence. Optometry and vision science : official publication of the American Academy of Optometry. 2015 May 1; 92(5):537-43.
  18. Sleath B, Blalock SJ, Carpenter DM, Sayner R, Muir KW, Slota C, Lawrence SD, Giangiacomo AL, Hartnett ME, Tudor G, Goldsmith JA, Robin AL. Ophthalmologist-patient communication, self-efficacy, and glaucoma medication adherence. Ophthalmology. 2015 Apr 1; 122(4):748-54.
  19. Sleath B, Sayner R, Blalock SJ, Carpenter DM, Muir KW, Hartnett ME, Tudor G, Lawrence S, Giangiacomo AL, Robin AL. Patient question-asking about glaucoma and glaucoma medications during videotaped medical visits. Health communication. 2014 Jul 25; 30(7):660-8.
  20. Sleath BL, Blalock SJ, Muir KW, Carpenter DM, Lawrence SD, Giangiacomo AL, Goldsmith JA, Hartnett ME, Slota C, Robin AL. Determinants of Self-Reported Barriers to Glaucoma Medicine Administration and Adherence: A Multisite Study. The Annals of pharmacotherapy. 2014 Jul 1; 48(7):856-862.
  21. Muir KW, Lim A, Stinnett S, Kuo A, Tseng H, Walsh MM. Risk factors for exposure of glaucoma drainage devices: a retrospective observational study. BMJ open. 2014 May 2; 4(5):e004560.
  22. Sleath B, Slota C, Blalock SJ, Sayner R, Carpenter DM, Muir KW, Hartnett ME, Robin AL. Provider use of collaborative goal setting with glaucoma patients. Optometry and vision science : official publication of the American Academy of Optometry. 2014 May 1; 91(5):549-55.
  23. Rosdahl JA, Swamy L, Stinnett S, Muir KW. Patient education preferences in ophthalmic care. Patient preference and adherence. 2014 Apr 25; 8:565-74.
  24. Sleath B, Blalock SJ, Carpenter DM, Muir KW, Sayner R, Lawrence S, Giangiacomo AL, Hartnett ME, Tudor G, Goldsmith J, Robin AL. Provider Education about Glaucoma and Glaucoma Medications during Videotaped Medical Visits. Journal of ophthalmology. 2014 Apr 24; 2014:238939.
  25. Freedman BL, Jones SK, Lin A, Stinnett SS, Muir KW. Vision-related quality of life in children with glaucoma. Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus / American Association for Pediatric Ophthalmology and Strabismus. 2014 Feb 1; 18(1):95-8.
  26. Williams AM, Allingham RR, Beckwith HS, Liu PJ, Santiago-Turla C, Muir KW. Patient and family attitudes about an eye donation registry for research. Current eye research. 2013 Sep 1; 38(9):945-51.
  27. Muir KW, Grubber J, Mruthyunjaya P, McCant F, Bosworth HB. Progression of diabetic retinopathy in the hypertension intervention nurse telemedicine study. JAMA ophthalmology. 2013 Jul 1; 131(7):957-8.
  28. Whitson HE, Whitaker D, Potter G, McConnell E, Tripp F, Sanders LL, Muir KW, Cohen HJ, Cousins SW. A low-vision rehabilitation program for patients with mild cognitive deficits. JAMA ophthalmology. 2013 Jul 1; 131(7):912-9.
  29. Muir KW, Christensen L, Bosworth HB. Health literacy and glaucoma. Current opinion in ophthalmology. 2013 Mar 1; 24(2):119-24.
  30. Muir KW, Gupta C, Gill P, Stein JD. Accuracy of international classification of diseases, ninth revision, clinical modification billing codes for common ophthalmic conditions. JAMA ophthalmology. 2013 Jan 1; 131(1):119-20.
  31. Sleath B, Blalock SJ, Covert D, Skinner AC, Muir KW, Robin AL. Patient race, reported problems in using glaucoma medications, and adherence. ISRN ophthalmology. 2012 Oct 15; 2012:902819.
  32. Muir KW, Alder B, Thomas A, Crowell SS, Stinnett SS, Lee PP. Trust in the provider and glaucoma-related blindness. ISRN ophthalmology. 2012 Jun 20; 2012:393917.
  33. Muir KW, Ventura A, Stinnett SS, Enfiedjian A, Allingham RR, Lee PP. The influence of health literacy level on an educational intervention to improve glaucoma medication adherence. Patient education and counseling. 2012 May 1; 87(2):160-4.
  34. Freedman RB, Jones SK, Lin A, Robin AL, Muir KW. Influence of parental health literacy and dosing responsibility on pediatric glaucoma medication adherence. Archives of Ophthalmology. 2012 Mar 1; 130(3):306-11.
  35. Sleath B, Blalock SJ, Stone JL, Skinner AC, Covert D, Muir K, Robin AL. Validation of a short version of the glaucoma medication self-efficacy questionnaire. The British journal of ophthalmology. 2012 Feb 1; 96(2):258-62.
  36. Sleath B, Blalock S, Covert D, Stone JL, Skinner AC, Muir K, Robin AL. The relationship between glaucoma medication adherence, eye drop technique, and visual field defect severity. Ophthalmology. 2011 Dec 1; 118(12):2398-402.
  37. Lim Z, Muir KW, Duncan L, Freedman SF. Acquired central corneal thickness increase following removal of childhood cataracts. American Journal of Ophthalmology. 2011 Mar 1; 151(3):434-41.e1.
  38. Lopez JP, Freedman SF, Muir K, Duncan L, Stephens D, Atenafu E, Levin AV. Central corneal thickness in children and adolescents with pediatric glaucoma and eye disorders at risk of developing glaucoma. Journal of pediatric ophthalmology and strabismus. 2011 Mar 1; 48(2):108-16.
  39. Muir KW, Bosworth HB, Lee PP. Health services research and how it can inform the current state of ophthalmology. American Journal of Ophthalmology. 2010 Dec 1; 150(6):761-3.
  40. Muir KW, Lee PP. Health literacy and ophthalmic patient education. Survey of ophthalmology. 2010 Sep 1; 55(5):454-9.
  41. Malone PE, Herndon LW, Muir KW, Jaffe GJ. Combined fluocinolone acetonide intravitreal insertion and glaucoma drainage device placement for chronic uveitis and glaucoma. American Journal of Ophthalmology. 2010 May 1; 149(5):800-6.e1.
  42. Muir KW, Lee PP. Literacy and informed consent: a case for literacy screening in glaucoma research. Archives of Ophthalmology. 2009 May 1; 127(5):698-9.
Journal Other

  1. Muir KW, Lee PP. Glaucoma medication adherence: room for improvement in both performance and measurement. [Editorial]. Archives of Ophthalmology. 2011 Feb 1; 129(2):243-5.
Book Chapters

  1. Novack GD, Muir KW, Newman-Casey PA, Robin AL. Ocular Hypotensive Medications: Adherence and Performance. In: Shaaraway TM, editor. Glaucoma: Medical Diagnosis and Therapy. 2 ed. New York, NY: Elsevier Saunders; 2015. 521-524 p.
  2. Lim A, Muir KW, Giaconi J. Glaucoma. In: Vickers L, Bhatti MT, editors. The Ophthalmology Clinical Trials Handbook. Hauppauge, NY: Nova Science Publishers; 2015. Chapter 4. 245-297 p.
Conference Presentations

  1. Kumar J, Muir KW. Comparing Medication Possession Ratio (MPR) versus electronic monitors to evaluate glaucoma medication non adherence. Poster session presented at: American Glaucoma Society Annual Meeting; 2015 Aug 17; Fort Lauderdale, FL.
  2. Rao V, Woolson S, Whigham BL, Coffman CJ, Muir KW. Laser Trabeculoplasty Practice Patterns In Relationship to Glaucoma Medication Adherence. Poster session presented at: American Glaucoma Society Annual Meeting; 2015 Aug 15; Fort Lauderdale, FL.
  3. Muir KW, Whigham B, Shieh C, Woolson S, Coffman CJ, Oddone EZ. The influence of oral statin medications on the progression of glaucoma. Poster session presented at: VA HSR&D / QUERI National Meeting; 2015 Jul 9; Philadelphia, PA.
  4. Badhwar J, Bosworth HB, Sleath B, Danus SM, Chritensen L, Muir KW. Evaluation of two metrics for identifying poor glaucoma medication adherence compared to objective adherence measurements. Poster session presented at: VA Durham VAMC Annual Research Week; 2014 May 13; Durham, NC.
  5. Badhwar j, Bosworth HB, Sleath B, Danus S, Christiansen L, Muir KW. Evaluation of two metrics for identifying poor glaucoma medication adherence compared to objective adherence measurements. Poster session presented at: Association for Research in Vision and Ophthalmology Annual Meeting; 2014 May 8; Orlando, FL.
  6. Muir KW, Bosworth HB. Progression of Diabetic Retinopathy in the Hypertension Intervention Nurse Telemedicine Study. Poster session presented at: VA Durham VAMC Annual Research Week; 2013 May 15; Durham, NC.
  7. Brown NH, Kubelick K, Stinnett SS, Epstein DL, Muir KW. An upright eye drop bottle. Poster session presented at: Association for Research in Vision and Ophthalmology Annual Meeting; 2013 May 7;
  8. Hansen MS, Muir KW, Tseng H, Kuo AN, Challa P, Santiago-Turla C, Ventura A, Walsh MM. Pilot study: The impact of advanced glaucoma on changes in aqueous outflow after cataract surgery. Poster session presented at: Association for Research in Vision and Ophthalmology Annual Meeting; 2012 May 5; Fort Lauderdale, FL.
  9. Muir KW, Alder B, Crowell SK, Stinnett SS, Thomas A, Lee PP. The relationship between trust, race, and glaucoma-related blindness. Poster session presented at: Association for Research in Vision and Ophthalmology Annual Meeting; 2012 May 5; Fort Lauderdale, FL.


DRA: Health Systems, Sensory Loss, Aging, Older Veterans' Health and Care
DRE: Treatment - Observational
Keywords: none
MeSH Terms: none

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